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Virchows Archiv A

, Volume 363, Issue 3, pp 213–224 | Cite as

The morphological and clinical features of membranoproliferative glomerulonephritis in adults

  • A. Bohle
  • H. V. Gärtner
  • H. Fischbach
  • K. D. Bock
  • H. H. Edel
  • U. Frotscher
  • R. Kluthe
  • W. Mönninghoff
  • F. Scheler
Article

Summary

A study of 110 patients with membranoproliferative glomerulonephritis (MPGN) revealed that this disease appears in a simple form and in a lobular form. Both forms are characterized by a differently severe proliferation of mesangial cells and by a mostly extensiv thickening of the glomerular basement membrane. The proliferation of mesangial cells and thickening of the glomerular basement membrane is more severe in the lobular form of MPGN. Dense deposit lesions were observed in association with both the simple form and the lobular form of MGPN. An analysis of the morphological and clinical features of MPGN in patients with dense deposits in the glomerular capillary walls failed to indicate that dense deposits represent a unique disease entity.

Keywords

Public Health Basement Membrane Simple Form Glomerulonephritis Mesangial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • A. Bohle
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • H. V. Gärtner
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • H. Fischbach
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • K. D. Bock
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • H. H. Edel
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • U. Frotscher
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • R. Kluthe
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • W. Mönninghoff
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  • F. Scheler
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
  1. 1.Institute of Pathology of the University of TübingenFederal Republic of Germany
  2. 2.Department of Internal Medicine of the University of EssenFederal Republic of Germany
  3. 3.Department of Internal Medicine of the University of MunichFederal Republic of Germany
  4. 4.Department of Internal Medicine of the University of BonnFederal Republic of Germany
  5. 5.Department of Internal Medicine of the University of FreiburgFederal Republic of Germany
  6. 6.Department of Internal Medicine of the University of MünsterFederal Republic of Germany
  7. 7.Department of Internal Medicine of the University of GöttingenFederal Republic of Germany

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