Abstract
7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in CSF was positively and significantly correlated to the serum level.
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Alfredsson, G., Lindberg, M. & Sedvall, G. The presence of 7-hydroxychlorpromazine in CSF of chlorpromazine-treated patients. Psychopharmacology 77, 376–378 (1982). https://doi.org/10.1007/BF00432774
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DOI: https://doi.org/10.1007/BF00432774