Abstract
Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems.
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Naik, S.R., Kelkar, M.R., Amladi, S.R. et al. Effect of muscimol, a central GABA receptor agonist, on the catalepsy, striatal homovanillic acid increase, and analgesia induced by pilocarpine in rats. Psychopharmacology 74, 393–394 (1981). https://doi.org/10.1007/BF00432756
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DOI: https://doi.org/10.1007/BF00432756