Abstract
Temperature and water intake were reduced to a greater degree in overiectomized female and normal male rats than in sham-operated female rats following an acute administration of 1 mg/kg of the anticholinesterase diisopropyl fluorophosphate (DFP). Ovariectomy also led to a significant reduction in the level of serum cholinesterase activity. These findings add further support for the hypothesis that the sex-dependent effects of DFP are due, at least in part, to sex differences in serum cholinesterase activity.
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References
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Overstreet, D.H., Russell, R.W., Kerni, W. et al. The influence of ovariectomy on the sex-dependent effects of the anticholinesterase diisopropyl fluorophosphate. Psychopharmacology 74, 391–392 (1981). https://doi.org/10.1007/BF00432755
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DOI: https://doi.org/10.1007/BF00432755