Psychopharmacology

, Volume 87, Issue 3, pp 351–356 | Cite as

Apomorphine anorexia: A behavioural and neuropharmacological analysis

  • Paul Willner
  • Anthony Towell
  • Richard Muscat
Original Investigations

Abstract

Anorectic effects of apomorphine were studied in a microstructural analysis paradigm. Low doses of apomorphine (<0.1 mg/kg SC) reduced food intake, by reducting both the rate of eating and eating time. The neuroleptics haloperidol and thioridazine blocked the effect of apomorphine on eating time, but not on eating rate. Anorectic effects elicited by apomorphine administration to the ventral tegmental area and, to a lesser extent, the substantia nigra were mediated by a selective reduction of eating time. Effects of apomorphine on eating time appear to result from an action at presynaptic dopamine receptors; the mechanism of the effect of apomorphine on eating rate is unclear.

Key words

Apomorphine Haloperidol Thioridazine Central drug administration Dopamine Feeding behaviour Microstructural analysis Eating rate Eating time Rat 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Paul Willner
    • 1
  • Anthony Towell
    • 1
  • Richard Muscat
    • 1
  1. 1.Psychology DepartmentCity of London PolytechnicLondonUK

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