, Volume 87, Issue 3, pp 272–277 | Cite as

Stereoselective behavioral effects of N6-phenylisopropyl-adenosine and antagonism by caffeine

  • Steven R. Goldberg
  • José A. Prada
  • Jonathan L. Katz
Original Investigations


Effects of the (-)- and (+)-isomers of N6-(phenylisopropyl)-adenosine (PIA) were studied in rats trained to respond under fixed-interval and fixed-ratio schedules of food reinforcement. Both isomers of PIA decreased response rates; however, the (-)-isomer decreased response rates at doses as low as 0.1 μM/kg and was 100–300 times more potent than the (+)-isomer. The potency differences suggest that the effects observed were due to actions at A1-adenosine receptors. Caffeine, an adenosine-receptor antagonist, when administered alone in doses of 10–154 μM/kg, increased response rates under the fixed-interval schedule and did not affect rates of responding under the fixed-ratio schedule. Higher doses decreased response rates under both schedules. Caffeine shifted the (-)-PIA dose-effect curve to the right. At a low dose of caffeine (25.7 μM/kg), which alone modestly increased response rates under the 5-min fixed-interval schedule, the disruptions in rates and patterns of responding produced by (-)-PIA were restored to resemble control performances. The higher dose of caffeine (77.2 μM/kg), which alone produced larger increases in rates of responding under the fixed-interval schedule, restored overall response rates to control levels when administered in combination with (-)-PIA. However, patterns of responding after the combination of doses remained disrupted. These effects suggest that some of the behavioral effects of caffeine are a result of mechanisms other than adenosine-receptor blockade.

Key words

N6-(phenylisopropyl)-adenosine Caffeine Schedule-controlled responding Fixed-interval schedule Fixed-ratio schedule 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Steven R. Goldberg
    • 1
    • 2
  • José A. Prada
    • 1
  • Jonathan L. Katz
    • 1
    • 2
  1. 1.NIDA Addiction Research CenterBaltimoreUSA
  2. 2.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA

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