Psychopharmacology

, Volume 74, Issue 2, pp 149–157 | Cite as

Pre-exposure effects of morphine, diazepam and Δ9-THC on the formation of conditioned taste aversions

  • L. Switzman
  • B. Fishman
  • Z. Amit
Original Investigations

Abstract

Prior to taste aversion conditioning with morphine, diazepam or Δ9-tetrahydrocannabinnol (Δ9-THC), rats received pre-exposures to the vehicle or one of the three drugs. Morphine pre-exposures blocked the aversion normally induced by morphine, but not by Δ9-THC or diazepam. Diazepam pre-exposures attenuated both the morphine- and diazepam-induced taste aversions to a significantly greater degree than the taste aversion induced by Δ9-THC. As a result of Δ9-THC pre-exposures, the aversions induced by diazepam and Δ9-THC were attenuated as well as the morphine-induced aversion, which was the most greatly attenuated. These results demonstrate that pre-exposure effects are not necessarily bi-directional and, moreover, they are inconsistent with current hypotheses which attempt to account for the attenuating effect of drug pre-exposures on taste-aversion conditioning.

Key words

Conditioned taste aversion Drug pre-exposure Morphine Diazepam Δ9-tetrahydrocannabinnol 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • L. Switzman
    • 1
  • B. Fishman
    • 1
  • Z. Amit
    • 1
  1. 1.Department of PsychologyConcordia University, Center for Research on Drug DependenceMontrealCanada

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