Virchows Archiv A

, Volume 376, Issue 2, pp 165–174 | Cite as

Degenerative processes in the pathogenesis of pulmonary alveolar lipoproteinosis

  • Danielle Jacobovitz-Derks
  • Bryan Corrin
Article

Summary

Electron microscopy in an infant of 4 months with pulmonary alveolar lipoproteinosis showed filling of the alveoli with osmiophilic lamellar bodies. Similar structures were present in the cytoplasm of type I alveolar epithelial cells and to a lesser extent in the capillary endothelium and interstitium. These changes represent widespread degenerative processes in the lung caused by an unidentified cytotoxic agent. In this patient the disease is comparable to the drug-induced cytotoxic animal model and differs from the dust-induced hypersecretory animal model.

Key words

Lung Electron microscopy Pulmonary alveolar proteinosis Degeneration 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Danielle Jacobovitz-Derks
    • 1
    • 2
  • Bryan Corrin
    • 1
    • 2
  1. 1.Hopital St PierreBrussels
  2. 2.Department of Morbid AnatomySt Thomas' HospitalLondonEngland

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