Morphometry of intrarenal arteries in progressive sclerosis
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Vessels of known position in the vascular tree of the kidneys of two cases with a long history of progressive systemic sclerosis — one normotensive, one hypertensive — were examined morphometrically.
Medial thickness, intimal thickness and the relative content of collagen and elastin in the vascular media were measured. Smooth muscle nuclei were counted in the arterial cross section.
These morphometric data were compared with those obtained from two autopsy cases — one with a history of essential hypertension, one without any hypertensive history. The findings suggest that progressive sclerosis induces intimal thickening in all branches of the renal artery down to a distented diameter of 200 μm.
In the case where progressive sclerosis was complicated by arterial hypertension increased medial thicknesses were found, similar to the findings in the case with a history of essential hypertension.
Key wordsProgressive sclerosis Morphometric investigation of intrarenal arteries Intimal thickening
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- Campbell, P.M., Le Roy, E.C.: Pathogenesis of systemic sclerosis: A vascular hypothesis. Semin. Artheritis Rheum. 4, 351–368 (1975)Google Scholar
- Cannon, P.J., Hassar, M., Case, D.B., Casarella, J.W., Sommers, S.C., Le Roy, E.C.: The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation. Medicine 53, 1–46 (1974)Google Scholar
- D'Angelo, W.A., Fries, J.F., Masi, T., Shalman, L.E.: Pathologic observations in systemic sclerosis (Scleroderma). Am. J. Med. 46, 428–440 (1969)Google Scholar
- Ehrenfeld, M., Licht, A., Stessmann, J., Yanko, L., Rosenmann, E.: Post-partum renal failure due to progressive systemic sclerosis treated with chronic haemodialysis. Nephron 18, 175–181 (1977)Google Scholar
- Fahr, Th.: Über Nephrosklerose. Virchows Arch. 226, 119–178 (1919)Google Scholar
- Fenell, J.R., Reddy, C.R.R.M., Vazquez, J.J.: Progressive systemic sclerosis and malignant hypertension. Arch. Path. 72, 209–215 (1961)Google Scholar
- Fischer, E.R., Rodnan, G.P.: Pathologic observations concerning the kidney in progressive systemic sclerosis. A.M.A. Arch. Pathol. 65, 29–39 (1958)Google Scholar
- Fischer, J.A.: Die Sklerodermieniere. Schweiz. Med. Wochenschr. 3, 140–146 (1963)Google Scholar
- Henrichs, K.J., Berry, C.L.: Morphometrische Untersuchungen an Arterien bei Hypertonie — im Tierexperiment und an menschlichem Untersuchsgut. Verh. Dt. Ges. Path. 63. Tagung, 1979Google Scholar
- Heptinstall, R.H.: Scleroderma. In: Pathology of the kidney, pp. 696–711. Boston: Little, Brown and Company 1974Google Scholar
- Kass, H., Hanson, V., Patrick, J.: The kidney in scleroderma. Lancet i, 68–70 (1952)Google Scholar
- Norton. W.L., Nardo, J.M.: Vascular disease in progressive systemic sclerosis (Scleroderma). Ann. Int. Med. 73, 317–324 (1970)Google Scholar
- Sackner, M.A.: Scleroderma. Modern medical monographs. New York: Grune and Stratton, Inc. 1966Google Scholar
- Treacy, W.L.: Scleroderma of the oesophagus: a correlation of histologic and physiologic findings. Ann. Int. Med. 59, 351–364 (1963)Google Scholar
- Vidt, D.G., Robertson, A.L., Deodhar, S.D.: Renal changes in progressive systemic sclerosis. Report of five cases. Cleve. Clin. Q. 38, 141–142 (1971)Google Scholar