Virchows Archiv A

, Volume 385, Issue 3, pp 271–282 | Cite as

Dermal dysplasia, hypotrichosis, and dorsal skin ulcers in adult NMRI-mice after X-irradiation in utero

  • W. Schmahl
  • E. Senft
  • V. Erfle
  • H. Kriegel
Original Articles


Prenatal X-irradiation in mice leads to a marked incidence of hypotrichosis and alopecia in offspring, when irradiation occurs during the stage of late organogenesis (day 11–13 p.c.). In addition, severe ulcerative dermatitis occurs in offspring starting at 2 months of age, with marked preference for those animals, which have been irradiated at least during days 11–13 p.c. This occurs without any dose dependence; application of doses between 2.4 Gy and 7.2 Gy results in approximately similar incidence rates of skin ulcers (range between 39.1 and 48.0%). There is no sex preference and no dependence on housing. At autopsy no special abnormalities were found in the internal organs with the exception of frequent signs of amyloidosis. This disease pattern could also be produced in germ-free animals. The intracutanous administration of skin extracts from affected animals into unirradiated mice leads to a marked infiltration of leukocytes. It is therefore suggested that prenatal X-irradiation induces a distinct dysplasia of the epidermis, which is followed by an endogenous leukotactic activity.

Key words

Skin dysplasia X-irradiation In utero 


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  1. Demmel, U.: Clinical aspects of congenital skin defects. Eur. J. Pediat. 121, 21–50 (1975)Google Scholar
  2. Elias, P.M., Mittermayer, H., Tappeiner, G., Fritsch, P., Wolff, K.: Staphylococcal toxic epidermal necrolysis: the expanded mouse model. J. Invest. Dermatol. 63, 467–475 (1974)Google Scholar
  3. Fox, J.G.: Ulcerative dermatitis in the rat. Lab. Animal Sci. 27, 671–675 (1977)Google Scholar
  4. Fritsch, P., Elias, P., Varga, J.: The fate of Staphylococcal exfoliatin in newborn and adult mice. Br. J. Dermatol. 95, 275–284 (1976)Google Scholar
  5. Gruneberg, H.: The development of some external features in mouse embryos. J. Heredity 34, 89–93 (1943)Google Scholar
  6. Haeffner, E.W., Privett, O.S.: Development of dermal symptoms resembling those of an essential fatty acid deficiency in immature hypophysectomized rats. J. Nutr. 103, 74–79 (1973)Google Scholar
  7. Hammarstrom, S., Hamberg, M., Samuelsson, B., Duell, E., Stawiski, M., Voorhees, J.: Increased concentrations of nonesterified arachidonic acid, prostaglandin E2, and prostaglandin F2 in epidermis of psoriasis. Proc. Natl. Acad. Sci. USA 72, 5130–5134 (1975)Google Scholar
  8. Hanson, J.: The histogenesis of the epidermis in the rat and mouse. J. Anat. 81, 174–197 (1947)Google Scholar
  9. Hardy, M.H.: The differentiation of hair follicles and hairs in organ culture. In: Advances in biology of skin, Vol. IX Hair growth, W. Montagna and R.L. Dobson (eds.), pp. 35–60. Oxford, New York: Pergamon Press 1969Google Scholar
  10. Hicks, S.P., O'Brien, R.C., Newcomb, E.C.: Developmental malformations produced by radiation. A timetable of their development. Am. J. Roentgenol. 69, 272–293 (1953)Google Scholar
  11. Hicks, S.P.: Radiation as an experimental tool in mammalian developmental neurology. Physiol. Rev. 38, 337–365 (1958)Google Scholar
  12. Kriegel, H., Shibata, K.: Histologische Untersuchungen über die Beeinflussung der Embryonal-entwicklung bei der Maus nach Röntgenbestrahlung. I. Mitteilung: Frühembryonale Veränderungen und Beeinflussung der Augenentwicklung. Strahlentherapie 124, 573–587 (1964)Google Scholar
  13. Lathrop, K.A., Gloria, J.V., Harper, P.V.: Response of the mouse fetus to radiation from Na99mTcO4. International Atomic Energy Agency Symposium No 202 p. 211–221 on Hazards of Internal Irradiation, Chicago, 1977Google Scholar
  14. Lazarus, G.S., Yost, F.J., Thomas, C.A.: Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis. Science 198, 1162–1163 (1977)Google Scholar
  15. Levine, N., Hatcher, V.B., Lazarus, G.S.: Proteinases of human epidermis; a possible mechanism for polymorphonuclear leukocyte chemotaxis. Biochim. Biophys. Acta 452, 458–467 (1976)Google Scholar
  16. Penneys, N.S., Ziboh, V., Simon, P., Lord, J.: Pathogenesis of Woronoff ring in psoriasis. Arch. Dermatol. 112, 955–957 (1976)Google Scholar
  17. Penneys, N.S., Lord, J.T., Ziboh, V.A., Simon, P.: Inhibitors of prostaglandin biosynthesis and epidermal injury. Prostaglandins 14, 355–362 (1977a)Google Scholar
  18. Penneys, N.S., Simon, P., Ziboh, V.A., Schlossberg, J.: In vivo chemotaxis induced by polyunsaturated fatty acids. J. Invest. Dermatol. 69, 435–438 (1977b)Google Scholar
  19. Reid, L.H., Weston, W.L., Humbert, J.R.: Staphylococcal scalded skin syndrome. Arch. Dermatol. 109, 239–241 (1974)Google Scholar
  20. Russell, L.B.: X-ray induced developmental abnormalities in the mouse and their use in the analysis of embryological patterns. I. External and gross visceral changes. J. Exp. Zool. 114, 545–601 (1950)Google Scholar
  21. Russell, L.B.: X-ray-induced developmental abnormalities in the mouse and their use in the analysis of embryologic patterns. II. Abnormalities of the vertebral column and thorax. J. Exp. Zool. 131, 329–395 (1956)Google Scholar
  22. Sengel, P.: Morphogenesis of skin. Cambridge: University Press 1976Google Scholar
  23. Thalhammer, O.: Pränatale Erkrankungen des Menschen. Stuttgart: Thieme 1967Google Scholar
  24. Tan, W.C., Privett, O.S.: Studies on the synthesis of prostaglandins in the vesicular glands of essential fatty acid-deficient and hypophysectomized rats. Biochim. Biophys. Acta 296, 586–592 (1973)Google Scholar
  25. Turner, S.R., Campbell, J.A., Lyun, W.S.: Polymorphonuclear leucocyte chemotaxis toward oxidized lipid cell components of cell membrane. J. Exp. Med. 141, 1437–1441 (1975)Google Scholar
  26. UNSCEAR-report on “Sources and Effects of Ionizing Radiation”, United Nations, New York, 1977Google Scholar
  27. Upton, A.C., Conklin, J.W., Popp, R.A.: Influence of age at irradiation on susceptibility to radiation-induced life-shortening in RF mice. In: Radiation and aging, pp. 337–344. P.J. Lindop and G.H. Sacher (eds.). London: Taylor and Francis 1966Google Scholar
  28. Wagner, J.E., Owens, D.R., La Regina, M.C., Vogler, G.A.: Self trauma and staphylococcus aureus in ulcerative dermatitis of the rat. J. Amer. Vet. Med. Assoc. 171, 839–841 (1977)Google Scholar
  29. Wessells, N.K., Roessner, K.D.: Nonproliferation in dermal condensations of mouse vibrissae and pelage hairs. Developm. Biol. 12, 419–433 (1965)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • W. Schmahl
    • 1
  • E. Senft
    • 1
  • V. Erfle
    • 2
  • H. Kriegel
    • 1
  1. 1.Abteilung für Nuklearbiologie der Gesellschaft für Strahlen- und Umweltforschung München (GSF-Munich)NeuherbergFederal Republic of Germany
  2. 2.Abteilung für Pathologie der Gesellschaft für Strahlen- und Umweltforschung München (GSF-Munich)NeuherbergFederal Republic of Germany

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