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Virchows Archiv A

, Volume 368, Issue 3, pp 253–274 | Cite as

Zur Ultrastruktur fibröser und histiocytärer Hauttumoren (Dermatofibrom, Dermatofibrosarcoma protuberans, Fibroxanthom und Histiocytom)

  • L. Auböck
Article

Zusammenfassung

Es wird über den Feinbau folgender Hauttumoren berichtet: Dermatofibrom (7 Fälle), Histiozytom (4 Fälle), Dermatofibrosarcoma protuberans (1 Fall) und Fibroxanthom (1 Fall). Aufgrund ihrer unterschiedlichen ultrastrukturellen Merkmale ist eine zweifache Unterteilung dieser Hauttumoren möglich: In eine Tumorgruppe, umfassend das Dermatofibrom, Dermatofibrosarcoma protuberans und Fibroxanthom, bei der die Faserbildung im Vordergrund steht und für deren Histogenese Fibroblasten angenommen werden können. Diese Tumortypen unterscheiden sich vom Histiozytom, dessen Zellcharakter vor allem durch die stark ausgeprägte Phagozytose- und Speichertätigkeit (Fett und Hämosiderin) bestimmt wird und für welches eine histogenetische Ableitung von Histiozyten wahrscheinlich ist. Die Zellkerne des Dermatofibromes und des Histiozytomes weisen einen einfachen Oberflächenverlauf auf, die des Dermatofibrosarcoma protuberans und Fibroxanthomes haben hingegen sehr stark gegliederte Formationen („Labyrinthkerne”). Diese Kernsegmentierung ist für das Dermatofibrosarcoma protuberans ein morphologisches Korrelat seiner Semimalignität. Eine Klassifizierung der faserbildenden Tumoren als „fibröse Histiozytome” erscheint aufgrund der ultrastrukturellen Analyse nicht gerechtfertigt.

The ultrastructure of fibrous and histiocytic skin tumors (dermatofibroma, dermatofibrosarcoma protuberans, fibroxanthoma, and histiocytoma)

Summary

A report on the ultrastructure of the following skin tumors: dermatofibroma (7 cases), histiocytoma (4 cases), dermatof ibrosarcoma protuberans (1 case), and fibroxanthoma (1 case). Because of their different ultrastructural characteristics a division into two groups is possible: one group of tumors would include dermatofibroma, dermatofibrosarcoma protuberans, and fibroxanthoma, where the formation of fibers is extensive and fibroblasts are suggested for its histogenesis. These types of tumor differ from histiocytoma, the cellular character of which is determined by a very pronounced phagocytosis and storage of lipid and hemosiderin; a histogenesis from histiocytes is probable. The nuclei of dermatofibroma and histiocytoma show a simple surfacedevelopment, whereas the nuclei of dermatofibrosarcoma protuberans and fibroxanthoma show multisegmented nuclei (“labyrinth nuclei”). In the case of dermatofibrosarcoma protuberans this kind of nuclear segmentation seems to be a morphologic correlate of its semimalignancy. Based on ultrastructural analysis a classification of these fiber-producing tumors into “fibrous histiocytomas” is not justified.

Key words

Tumors of the skin Histogenesis Classification Labyrinth nuclei Electron microscopy 

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Literatur

  1. Adams, J. T., Salzstein, S. L.: Metastazing dermatofibrosarcoma protuberans: report of two cases. Amer. J. Surg. 29, 879–886 (1963)Google Scholar
  2. Altmann, H. W., Müller, H. A.: Grundlagen der Karyologie. Verh. dtsch. Ges. Path. 57, 2 (1973)Google Scholar
  3. Arning, E., Lewandowski, F.: Noduli cutanei, eine bisher wenig beachtete Hautaffektion. Arch. Derm. Syph. (Berl.) 110, 1–14 (1911)Google Scholar
  4. Bednar, B.: Storiform neurofibromas of the skin, pigmented and nonpigmented. Cancer (Philad.) 10, 368–376 (1957)Google Scholar
  5. Bednar, B.: Storiform neurofibroma in core of naevocellular naevi. J. Path. 101, 199–201 (1970)Google Scholar
  6. Bernstein, J. C.: Hemosiderin histiocytoma of the skin. Arch. Derm. Syph. (Chic.) 40, 390–396 (1939)Google Scholar
  7. Binkley, G. W.: Dermatofibrosarkoma protuberans: report of six cases. Arch. Derm. Syph. (Chio.) 40, 578–594 (1939)Google Scholar
  8. Breathnach, A. S.: The Ultrastructure of human skin, p. 82–84, p. 176. London: J. and A. Churchill 1971Google Scholar
  9. Burkhardt, B. R., Soule, E. H., Winkelmann, R. K., Ivins, J. C.: Dermatofibrosarkoma protuberans. Study of fifty-six cases. Amer. J. Surg. 111, 638–644 (1966)Google Scholar
  10. Burri, P. H., Weibel, E. R.: Beeinflussung einer spezifischen cytoplasmatischen Organelle von Endothelzellen durch Adrenalin. Z. Zellforsch. Mikroskop. Anat. 88, 426–440 (1968)Google Scholar
  11. Carstens, H. B., Schrodt, G. R.: Ultrastructure of sclerosing hemangioma. Amer. J. Path. 77, 377–382 (1974)Google Scholar
  12. Civatte, A.: Fibrome en pastille. Marseille méd. 65, 365–373 (1928)Google Scholar
  13. Comings, D. E., Okada, T. A.: Electron microskopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth. Exp. Cell Res. 61, 295–301 (1970)Google Scholar
  14. Darier, J., Ferrand, M.: Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peau. Ann. Derm. Syph. 5, 545–562 (1924)Google Scholar
  15. Eisenstein, R.: Giant cell tumor of tendon sheath. J. Bone Jt Surg. 58, 476–486 (1968)Google Scholar
  16. Enzinger, F. M., Lattes, R., Torloni, H.: Histological typing of soft tissue tumors. International Histological Classification of Tumors. No. 3. Geneva: World Health Organization 1969Google Scholar
  17. Fawcett, D. W.: An atlas of fine structure: The cell. Philadelphia, Pennsylvania: Saunders 1966Google Scholar
  18. Fawcett, D. W.: On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates. Amer. J. Anat. 119, 129–146 (1966)Google Scholar
  19. Fawcett, D. W.: Atlas zur Elektronenmikroskopie der Zelle. München-Berlin-Wien: Urban & Sohwarzenberg 1973Google Scholar
  20. Fisher, E. R., Hellstrom, H. R.: Dermatofibrosarcoma with metastases simultating Hodkin's disease and reticulum cell sarcoma. Cancer (Philad.) 19, 1165–1171 (1966)Google Scholar
  21. Fisher, E. R., Vuzevski, V. D.: cytogenesis of schwannoma, neurofibroma dermatofibroma, and dermatofibrosarcoma as revealed by electron microscopy. Amer. J. clin. Path. 49, 141–154 (1968)Google Scholar
  22. Frenk, E.: Zur Histologie der Fibrome und Histiozytome der Haut. Hautarzt 12, 15–19 (1961)Google Scholar
  23. Fujita, H.: Studies of mesodermal tumors: II. Dermatofibosarcoma protuberans. Acta derm. (Kyoto) 57, 4–6 (1962)Google Scholar
  24. Ghadially, F. N., Janzen, H. K., Mehta, P. N.: Synovial membrane in experimental lipoarthrosis. Arch. Path. 89, 291–301 (1970)Google Scholar
  25. Ghidoni, J. J., O'Neal, R. M.: Recent advances in molecular pathology: A riew Ultrastructure of human atheroma. Exp. molec. Path. 7, 378–400 (1967)Google Scholar
  26. Gieseking, R.: Submikroskopische Unterschiede zwischen Histiozyten und Fibroblasten. Beitr. path. Anat. 128, 259–282 (1963)Google Scholar
  27. Gieseking, R.: Ultramorphologie Arch. Derm. Forsch. 244, 124–130 (1972)Google Scholar
  28. Gottron, H. A., Nikolowski, W.: Sarkom der Haut. In: Dermatologie und Venerologie, hrsg. v. H. A. Gottron und W. Schönfeld, Bd. IV. Stuttgart: G. Thieme 1960Google Scholar
  29. Grimley, P. M., Sokoloff, L.: Synovial giant cells in rheumatoid arthritis. Amer. J. Path. 49, 931–954 (1966)Google Scholar
  30. Groetschel, H., Cramer, H. J.: Multilokulär-symetrisches Dermatofibrosarkoma protuberans. Derm. Wschr. 153, 579–582 (1967)Google Scholar
  31. Gross, R. E., Wolbach, S. B.: Sclerosing hemangiomas: their relationsship to dermatofibroma, histiozytoma, xanthoma and to certain pigmented lesions of the skin. Amer. J. Path. 19, 533–551 (1943)Google Scholar
  32. Gusek, W.: Submikroskopische Untersuchungen zur Feinstruktur aktiver Bindegewebszellen. In: Veröffentlichungen aus der morphologischen Pathologie, H. 64. Stuttgart: G. Fischer 1962Google Scholar
  33. Hagedorn, M., Thomas, C., von Kannen, W.: Dermatofibrosarcoma protuberans mit Übergang in ein sog. Fibrosarkom. Dermatologica (Basel) 149, 84–89 (1974)Google Scholar
  34. Hamamatsu, T., Morohashi, M., Suzuki, K.: Dermatofibrosarcoma protuberans. Rinsho Dermatol. 10, 798–811 (1968)Google Scholar
  35. Hashimoto, K., Lever, W. F.: Kaposis's Sarcoma. Histochemical and electron microscopic studies. J. invest. Derm. 43, 539–549 (1964)Google Scholar
  36. Hoffmann, E.: Über das knollentreibende Fibrosarkom (dermatofibrosarcoma protuberans). Derm. Z. 43, 1–25 (1925)Google Scholar
  37. Hueck, W.: Zur Morphologie der epithelialen Tumoren, insbesondere der Basaliome. Virchows Archiv. path. Anat. 314, 137–161 (1947)Google Scholar
  38. Jasmin, G., Riopello, J. L.: Tumeur du pavillon de l'oreille induite chez le rat par le diméthylbenzanthracene. Virchows Arch. Abt. B 10, 30–39 (1972)Google Scholar
  39. Kamensky, E., Philippart, M., Cancilla, P., Frommes, S. P.: Cultured skin fibroblasts in storage disorders. Amer. J. Path. 73, 59–72 (1973)Google Scholar
  40. Kempson, R. L., Kyriakos, M.: Fibroxanthosarcoma of the soft tissues. Cancer (Philad.) 29, 961–976 (1972)Google Scholar
  41. Kint, A., Geerts, M. L.: Pseudosarcome der Haut. In: Fortschritte der praktischen Dermatologie und Venerologie, hrsg. v. O. Braun-Falco u. D. Petzoldt, Bd. 7. Berlin-Heidelberg-New York: Springer 1973Google Scholar
  42. Klaus, S. N., Winkelmann, R. K.: The enzyme histochemistry of nodular subepidermal fibrosis. Brit. J. Derm. 78, 398–402 (1966)Google Scholar
  43. Mackenzie, D. H.: The differential diagnosis of fibroblastic disorders. Oxford and Edinburgh: Blackwell Scientific Publications 1970Google Scholar
  44. Matsuda, H., Sugiura, S.: Ultrastructure of “tubular body” in the endothelial cells of the ocular blood vessels. Invest. Ophthal. 9, 919–925 (1970)Google Scholar
  45. McPeak, C. J., Cruz, T., Nicastri, A. D.: Dermatofibrosarcoma protuberans. An analysis of 86 cases—five with metastasis. Ann. Surg. 166, 803–816 (1967)Google Scholar
  46. Michelson, H. E.: Nodular subepidermal fibrosis. Arch. Derm. 27, 812–820 (1933)Google Scholar
  47. Mihatsch-Konz, B., Schaumburg-Lever, G., Lever, W. F.: Ultrastructure of dermatofibroma. Arch. Derm. Forsch. 246, 181–192 (1973)Google Scholar
  48. Mopper, C., Pinkus, H.: Dermatofibrosarcoma protuberans. Amer. J. clin. Path. 20, 171–176 (1950)Google Scholar
  49. Müllejans, H. N.: Das Dermatofibrom. Untersuchungen zur elektronenmikroskopischen Struktur. Inaug.-Diss. Med. Fak. Univ. Bonn (1970)Google Scholar
  50. Niemi, K. M.: The benign fibrohistiocytic tumours of the skin Acta derm. -venereol. (Stockh.), 50 Suppl. 63 (1970)Google Scholar
  51. Ozzello, L., Stout, A. P., Murray, M. R.: Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer (Philad.) 16, 331–344 (1963)Google Scholar
  52. Pack, G. T., Tabah, E. J.: Dermatofibrosarcoma protuberans. A report of thirty-nine cases. Arch. Surg. 62, 371–411 (1951)Google Scholar
  53. Patrizi, G., Poger, M.: The ultrastructure of the nuclear periphery. J. Ultrastruct. Res. 17, 127–136 (1967)Google Scholar
  54. Penner, D. W.: Metastasizing dermatofibrosarcoma protuberans; case report. Cancer (Philad.) 4, 1083–1086 (1951)Google Scholar
  55. Petkov, I., Andreev, V. C.: Dermatofibrosarcoma protuberans in seltener Lokalisation. Hautarzt 23, 508–510 (1972)Google Scholar
  56. Phelan, J. T., Juardo, J.: Dermatofibrosarcoma protuberans. Amer. Surg. 106, 943–948 (1963)Google Scholar
  57. Pinkus, H., Mehregan, A. H.: Tumoren der Haut. In: Spezielle pathologische Anatomie, Bd. 7, S. 529–629. Berlin-Heidelberg-New York: Springer 1973Google Scholar
  58. Przybora, L. C., Wojnerowicz, C.: Malignancy of dermatofibrosarcoma protuberans and report of 2 cases with lymphgland metastases. Oncologia (Basel) 12, 236–254 (1959)Google Scholar
  59. Rentiers, P. L., Montgomery, H.: Nodular subepidermal fibrosis (dermatofibroma versus histiocytoma). Arch. Derm. Syph. (Chic.) 59, 568–583 (1949)Google Scholar
  60. Ross, R., Benditt, E. P.: Wound healing and collagen formation. V. Quantitative electron microscope radioautographic observations of proline-H3 utilization by fibroblasts. J. Cell Biol. 27, 83–106 (1965)Google Scholar
  61. Roy, S., Ghadially, F. N.: Synovial membrane in experimentally produced chronic haemarthrosis. Ann. rheum. Dis. 28, 402–414 (1969)Google Scholar
  62. Ryan, G. B., Cliff, W. J., Gabbiani, G., Irle, C., Montandon, D., Statkov, P. R., Majno, G.: Myofibroblasts in human granulation tissue. Hum. Pathology 5, 55–67 (1974)Google Scholar
  63. Santolaya, R. C., Bertini, F.: Fine structure of endothelial cells of vertebrates: distribution of dense granules. Z. Anat. Entwickl.-Gesch. 131, 148–155 (1970)Google Scholar
  64. Sauter, L. S., DeFeo, C. P.: Dermatofibrosarcoma protuberans of the face. Arch. Derm. (Chic.) 104, 671–673 (1971)Google Scholar
  65. Schreus, H.: Dermatofibroma lenticulare. Arch. klin. exp. Derm. 161, 456–461 (1930)Google Scholar
  66. Senear, F. E., Caro, M. R.: Histiocytoma cutis. Arch. Derm. Syph. 33, 209–226 (1936)Google Scholar
  67. Smith, J. L. Jr.: Tumors of the Corium. In: Helwig, E. B., Mostofi, F. K., (eds.), The skin, p. 533–577. Baltimore: Williams & Wilkins Co. 1971Google Scholar
  68. Soule, E. H., Enriquez, P.: Atypical fibrous histiocytoma, malignant fibrous histiocytoma, malignant histiocytoma and epitheloid sarcoma—A comparative study of 65 tumors. Cancer (Philad.) 30, 128–143 (1972)Google Scholar
  69. Steigleder, G. K.: Neoplastisch wuchernde Zellen der Cutis und Subcutis. Handbuch der Haut- und Geschlechtskrankheiten, Ergänzungswerk, Bd. I, Teil 2, S. 708. Berlin-Göttingen-Heidelberg-New York: Springer 1964Google Scholar
  70. Steiner, G. C., Ghosh, L., Dorfman, H. D.: Ultrastructure of giant cell tumors of bone. Human Path. 3, 569–586 (1972)Google Scholar
  71. Steinsiepe, K. F., Weibel, E. R.: Elektronenmikroskopische Untersuchungen an spezifischen Organellen von Endothelzellen des Frosches (Rana temporaria) Z. Zellforsch. 108, 105–126 (1970)Google Scholar
  72. Stout, A. P., Lattes, R.: Tumors of soft tissues. In: Atlas of tumor pathology. Second ser., fasc. I, p. 38–52 and 107–115. Washington: Armed Forces Institute of Pathology 1967Google Scholar
  73. Taylor, H. B., Helwig, E. B.: Dermatofibrosarcoma protuberans. A study of 115 cases. Cancer (Philad.) 15, 717–725 (1962)Google Scholar
  74. Theron, J. J., Hawtrey, A. O., Liebenberg, N., Schirren, V.: The pathogenesis of experimental dietary siderosis of the liver. Amer. J. Path. 43, 73–91 (1963)Google Scholar
  75. Traub, E. F., Monash, S.: Dermatofibroma: report of cases. Arch. Derm. Syph. (Chic.) 26, 250–255 (1932)Google Scholar
  76. Tremblay, M., Bonenfant, J. L., Cliche, J.: Le dermatofibrosarcome protuberant; étude clinico-pathologique de 30 cas avec l'ultrastructure de 2 cas. Un. méd. Can. 99, 871–876 (1970)Google Scholar
  77. Unna, P.: Die Histopathologie der Hautkrankheiten. Berlin: A. Hirschwald 1894Google Scholar
  78. Weibel, E. R., Palade, G. E.: New cytoplasmic components in arterial endothelia. J. Cell Biol. 23, 101–112 (1964)Google Scholar
  79. Wooldridge, W. E.: Dermatofibrosarcoma protuberans; tumor too lightly-considered. Arch. Derm. (Chic.) 75, 132–134 (1957)Google Scholar
  80. Woringer, F.: Histiocytome xanthelasimèdu mollet. Bull. Soc. franç. Derm. Syph. 38, 1401–1405 (1931)Google Scholar
  81. Woringer, F.: Tumeurs conjunctives benignes. In: Nouvelle pratique dermatol. Hrsg. Darier, Civatte, Flandin, Tzanck, vol. VI, p. 555, Paris: Masson & Co. 1936Google Scholar
  82. Woringer, F., Kviatowski, S. L.: L'histiocytome de la peau. Ann. Derm. Syph. (Paris) 3, 998–1010 (1932)Google Scholar
  83. Zelickson, A. S.: A tubular structure in the endothelial cells and pericytes of human capillaries. J. invest. Derm. 46, 167–185 (1966)Google Scholar
  84. Zelickson, A. S.: Ultrastructure of normal and abnormal skin. Philadelphia: Lea & Febinger 1967Google Scholar

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© Springer-Verlag 1975

Authors and Affiliations

  • L. Auböck
    • 1
  1. 1.Abteilung für Elektronenmikroskopie des Instituts für Pathologische Anatomie der Universität GrazÖsterreich

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