Abstract
We investigated the effect of naloxone on the concentration of dopamine in the hypothalamus and on the concentration of prolactin in serum and anterior pituitary of male rats acutely treated with ethanol. Acute ethanol administration increased serum prolactin levels and hypothalamic dopamine concentration. Pituitary prolactin was not modified by this treatment. Naloxone administered 15 min before the animals were sacrificed decreased serum prolactin levels and hypothalamic dopamine concentration in ethanol-treated rats. These results suggest that ethanol increases prolactin secretion because it decreases the release of dopamine by the hypothalamus. Naloxone decreases prolactin release probably because it antagonizes the inhibitory action of opioids on dopaminergic neurons.
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References
Bacopoulus NG (1981) High-affinity stereospecific binding of 3H-dopamine in rat brain: interaction with endogenous dopamine. Biochem Pharmacol 30:2037–2040
Blum K, Hamilton MG, Wallace JE (1977) Alcohol and opiates: A review of common neurochemical and behavioral mechanisms. In: Blum K (ed) Alcohol and opiates, New York, Academic Press, pp 203–236
Carlsson A, Linquist M (1973) Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo. J Pharm Pharmacol 25:437–440
Darden JH, Hunt WA (1977) Reduction of striatal dopamine release during ethanol withdrawal syndrome. J Neurochem 29:1143–1145
Ferland L, Fuxe K, Eneroth P, Gustaffson J, Skett P (1977) Effects of methionine-enkephalin on prolactin release and catecholamine levels and turnover in the median eminence. Eur J Pharmacol 43:89–90
Gianoulakis C (1983) Long therm ethanol alters the binding of 3H-opiates to brain membranes. Life Sci 33:727–735
Gintzler AR, Scalisi JA (1983) Opioid-mediated acute responses to ethanol: Ethanol potentiates opioid actions on the guinea pig ileum. Brain Res 269:391–394
Grossman A, Rees LH (1983) The neuroendocrinology of opioid peptides. Br Med Bull 39:83–88
Gudelsky GA, Porter JC (1979) Morphine and opioid peptideinduced inhibition of the release of dopamine from the tuberoinfundibular neurons. Life Sci 25:1679–1702
Hoffman PL, Tabakoff B (1977) Alterations in dopamine receptor sensitivity by chronic ethanol treatment. Nature (London) 268:551–553
Hoffman PL, Urwyler S, Tabakoff B (1982) Alteration in opiate receptor function after chronic ethanol exposure. J Pharmacol Exp Ther 222:182–189
Hunt WA (1981) Neurotransmitter function in the basal ganglia after acute and chronic ethanol treatment. Fed Proc 40:2077–2081
Hymson DL, Sakai KK (1980) Acute ethanol intoxication and its relation to Beta-endorphin levels in rat plasma. Fed Proc 39:993
Loh HH, Brase D, Sampath-Khanna S, Mar JB, Way EL, Li CH (1976) Endorphin in vitro inhibition of striatal dopamine release. Nature (London) 264:567–568
Meites J, Bruni JF, Van Vugt DA, Smith AF (1979) Relation of endogenous opioid peptides and morphine to neuroendocrine functions. Life Sci 24:1325–1336
Meites J (1984) Effects of opiates on neuroendocrine functions in animals: Overview. In: Delitalia G et al. (eds) Opioid modulation of endocrine function. New York, Raven Press, pp 53–63
Muller P, Britton RS, Seeman P (1980) The effects of long-therm ethanol on brain receptors for dopamine, acetylcholine, serotonin and noradrenaline. Eur J Pharmacol 65:31–37
Neil JD (1980) Neuroendocrine regulation of prolactin secretion. In: Martini L, Ganong WF (eds) Frontiers in neuroendocrinology. New York, Raven Press, pp 129–155
Niswender GD, Chen CL, Midgley AR, Jr, Meites J, Ellis S (1969) Radioimmunoassay for rat prolactin. Proc Soc Exp Biol Med 130:793–797
Rabin RR, Molinoff PB (1981) Activation of adenylate cyclase by ethanol in mouse striatal tissue. J Pharmacol Exp Ther 216:129–134
Reinhard JF, Jr, Roth RH (1982) Noradrenergic modulation of serotonin by clonidin “in vivo”. J Pharmacol Exp Ther 221:541–546
Schulz R, Wüster M, Duka T, Herz A (1980) Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. Psychopharmacology 68:221–227
Seilicovich A, Rettori V, Koch OR, Duvilanski B, Diaz MC, Debeljuk L (1982) The effect of acute and chronic ethanol administration on prolactin secretion in male rats. J Androl 3:344–348
Seilicovich A, Duvilanski B, Debeljuk L, Diaz MC, Rettori V (1984a) Efecto de la adminstración aguda de etanol sobre la respuesta hipofisaria a la sulpirida en ratas tratadas con α-metil-p-tirosina y dietilditiocarbamato. Neur Lat 1:22–24
Seilicovich A, Duvilanski BH, Debeljuk L, Díaz MC, Muñoz Maines V, Rettori V (1984b) The effect of ethanol on prolactin secretion in vitro. Life Sci 35:1931–1935
Winer BJ (1971) Statistical principles in experimental design. New York, Mc Graw-Hill
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Seilicovich, A., Rubio, M., Duvilanski, B. et al. Inhibition by naloxone of the rise in hypothalamic dopamine and serum prolactin induced by ethanol. Psychopharmacology 87, 461–463 (1985). https://doi.org/10.1007/BF00432513
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DOI: https://doi.org/10.1007/BF00432513