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Membranoproliferative glomerulonephritis in systemic sclerosis of childhood

Virchows Archiv A volume 379, pages 169–179 (1978)Cite this article

Summary

The renal lesions of a 5-year-old girl with progressive systemic sclerosis are described. The nephropathy was clinically characterised by moderate proteinuria, microscopic hematuria and transient hypertension. Light microscopy showed membranoproliferative glomerulonephritis of segmental character. On electron microscopy intramesangial, subendothelial and extramembranous glomerular deposits were observed. By immunofluorescence microscopy deposits of IgG, Clq, C4, C3, C5, C8 und C9 in a predominantly subendothelial location were found in all glomeruli. Vascular lesions were of minor degree. Histological and immunohistological findings are compatible with an immune complex disease.

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Affiliations

  1. Institute of Pathology, Institute of Immunology and Department of Pediatrics, University of Heidelberg, Federal Republic of Germany

    R. Waldherr, H. -P. Seelig, B. Klare & J. Abigt

  2. Department of Pediatrics, University of Ulm, Federal Republic of Germany

    R. Waldherr, H. -P. Seelig, B. Klare & J. Abigt

Authors
  1. R. Waldherr
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  2. H. -P. Seelig
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  3. B. Klare
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  4. J. Abigt
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Waldherr, R., Seelig, H.P., Klare, B. et al. Membranoproliferative glomerulonephritis in systemic sclerosis of childhood. Virchows Arch. A Path. Anat. and Histol. 379, 169–179 (1978). https://doi.org/10.1007/BF00432486

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  • DOI: https://doi.org/10.1007/BF00432486

Key words

  • Progressive systemic sclerosis in childhood
  • Segmental membranoproliferative glomerulonephritis
  • Immune complex disease