Virchows Archiv A

, Volume 379, Issue 2, pp 157–168 | Cite as

Fine structure of multiple neonatal haemangioendothelioma of the liver

  • Márta Balázs
  • J. Denes
  • V. F. Lukács
Original Articles


This paper discusses the fine structure of multiple haemangioendothelioma of the liver. There have been no previous reports of electron microscopic studies of this tumour, which was found to be composed of young capillaries continuous in type and varying in calibre. The capillaries were lined by actively proliferating, immature endothelial cells with pericytes forming an integral part of the tumour. Their morphological characteristics indicated intensive protein production. The authors suggest that the active pericytes play a role in the production of reticular fibres of the tumour.

Following corticosteroid therapy, regression of tumour nodules occurred in this case in the interval between surgery and autopsy. This was confirmed by histological studies. The results seem to support the hypothesis that actively proliferating, young endothelial cells show an increased sensitivity to corticosteroids.

Key words

Endothelial cells Pericytes Basement membrane Reticular fibres 


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  1. Andersen, L., Fejerskon, O., Theilade, J.: Oral giant cell granulomas. An ultrastructural study of the vessels. Acta path. microbiol. scand. Sect. A. 83, 69–76 (1975)Google Scholar
  2. Blumenfeld, T.A., Fleming, I.D., Johnson, W.W.: Juvenile haemangioendothelioma of the liver. Report of a case and review of the literature. Cancer. 24, 853–857 (1969)Google Scholar
  3. Bommer, G., AltenÄhr, E., Kühnau, J., Klöppel, G.: Ultrastructure of hemangiopericytoma associated with Paraneoplastic Hypoglycemia. Z. Krebsforsch. 85, 231–241 (1976)Google Scholar
  4. Braun, P., Ducharme, J.S., Davignon, A.: Hémangiomatose hépatique du nourisson: Diagnostic et traitment. Helv. Paediat. Acta. 30, 159–167 (1975)Google Scholar
  5. Bruns, R.R., Palade, G.E.: Studies on blood capillaries. J. Cell. Biol. 37, 244–276 (1968)Google Scholar
  6. Danz, M., Katenkamp, D. Katenkamp, D., Ruffert, K.: Zur Frage der morphologischen Differentialdiagnose von HÄmangioendotheliom und HÄmangiosarkom. Zbl. allg. Path. 113, 331–342 (1970)Google Scholar
  7. Dehner, L.P., Ishak, K.G.: Vascular tumors of the liver in infants and children. A study of 30 cases and review of the literature. Arch. Path. 92, 101–111 (1971)Google Scholar
  8. Fuchs, U.: Die feinmikroskopische Struktur des KapillÄren HÄmangioma des Menschen. Beitr. path. Anat. 135, 309–321 (1967)Google Scholar
  9. Haustein, U.F., Klug, H.: Zur Ultrastruktur der Hautkapillaren bei Lupus Erythematodes, Dermatomyositis und Progressiver Sklerodermie. Derm. Mschr. 161, 353–363 (1975)Google Scholar
  10. Laird, W.P., Friedman, S., Koop, C.E., Schwartz, G.J.: Hepatic hemangiomatosis. Successful management by hepatic artery ligation. Am. J. Dis. Child. 130, 657–659 (1976)Google Scholar
  11. Ludwig, J., Hoffmann, H.N.: Hemangiosarcoma of the liver. Spectrum of morphologic changes and clinical findings. Mayo Clinic Proc. 50, 255–263 (1975)Google Scholar
  12. McLean, R.H., Moller, J.H., Walwick, W.J., Satran, L., Lucas, R.V.: Multinodular haemangiomatosis of the liver in infancy. Pediatrics. 49, 563–573 (1972)Google Scholar
  13. Murad, T.M., Von Haam, E., Murthy, M.S.W.: Ultrastructure of a haemangiopericytoma and a glomus tumor. Cancer 22, 1239–1249 (1968)Google Scholar
  14. Ramsey, H.J.: Fine structure of hemangiopericytoma and hemangioendothelioma. Cancer. 19, 2005–2018 (1966)Google Scholar
  15. Rocchini, A.P., Rosenthal, A., Issenberg, H.J., Madas, A.S.: Hepatic Hemangioendothelioma: Haemodynamic observations and treatment. Pediatrics. 57, 131–136 (1976)Google Scholar
  16. Schiliro, G., Guarneri, B., Russo, A.: A case of multiple neonatal haemangiomatosis with favourable outcome following steroid therapy. Acta Paediatr. Scand. 65, 267–270 (1976)Google Scholar
  17. Schoefl, G.I.: Studies on inflammation. III. Growing capillaries: Their structure and permeability. Virch. Arch. path. Anat. 337, 97–141 (1963)Google Scholar
  18. Silverberg, S.G., Willson, M.A., Board, J.A.: Hemangiopericytoma of the uterus: An ultrastructural study. Amer. J. Obstet. Gynec. 110, 397–404 (1971)Google Scholar
  19. Simon, G.: über die Struktur der Kapillarwand. Elektronenmikroskopische Untersuchungen. Münch. med. Wschr. 108, 1281–1287 (1966)Google Scholar
  20. Stehbens, W.E., Ludatscher, R.M.: Fine structure of senile angiomas of human skin. Angiology. 19, 581–592 (1968)Google Scholar
  21. Steiner, G.C., Dorman, H.D.: Ultrastructure of hemangio-endothelial sarcoma of bone. Cancer. 29, 122–135 (1972)Google Scholar
  22. Stiller, D., Katenkamp, D., Küttner, K.: Cellular Differentiations and Structural Characteristics in Nasopharyngeal Angiofibromas. An Electron-Microscopic Study. Virch. Arch. A. Path. Anat. Histol. 371, 273–282 (1976)Google Scholar
  23. Touloukian, R.J.: Hepatic haemangioendothelioma during infancy: pathology, diagnosis and treatment with predinsone. Pediatrics. 45, 71–76 (1970)Google Scholar
  24. Weibel, E.R., Palade, G.E.: New cytoplasmic components in arterial endothelia. J. Cell. Biol. 23, 101–103 (1964)Google Scholar
  25. Willis, R.A.: Pathology of Tumours. 5th ed. p. 726. London: Butterworths 1967Google Scholar
  26. Zarem, H.A., Edgerton, M.T.: Induced resolution of cavernous hemangiomas following prednisolone therapy. Plast. Reconstr. Surg. 39, 76–83 (1967)Google Scholar
  27. Zweifach, D.W.: The influence of the adrenal cortex on behaviour of the terminal vascular bed. Ann. N.Y. Acad. Sci. 56, 626–630 (1953)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Márta Balázs
    • 1
    • 2
  • J. Denes
    • 1
    • 2
  • V. F. Lukács
    • 1
    • 2
  1. 1.Department of PathologyJános HospitalHungary
  2. 2.1st Department of Surgery and 3rd Department of PediatricsApathy Children's HospitalBudapestHungary

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