Abstract
Animals with septal lesion-induced reactivity were injected with 2 dose levels of morphine in the periaqueductal-periventricular gray. Both doses of morphine transiently attenuated the reactivity. Naloxone injected IP significantly antagonized the morphine attenuation of the septal-lesion induced reactivity.
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References
Brady JV, Nauta WJH (1953) Subcortical mechanisms in emotional behavior: Affective changes following septal forebrain lesions in the albino rat. J Comp Physiol Psychol 46:339–346
Freeman W, Watts JW (1948) Pain mechanisms and the frontal lobes: A study of prefrontal lobotomy for intractable pain. Ann Intern Med 28:747
Gage FH, Olton DS (1976) L-Dopa reduces hyperreactivity induced by septal lesions in rats. Behav Biol 17:213–217
Marshall JF, Teitelbaum P (1974) Further analysis of sensory inattention following lateral hypothalamic damage in rats. J Comp Physiol Psychol 86:375–395
Jacquet YF, Lajtha A (1974) Paradoxical effects after microinjection of morphine in the periaqueductal gray matter in the rat. Science 185:1055–1057
Sharp LG, Garnett JE, Cicero TJ (1974) Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter in the rat. Behav Biol 11:303–313
Yaksh TL, Yeung JC, Rudy TA (1976) Systemic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray. Brain Res 114:83–103
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Gage, F.H., Valdes, J.J. & Thompson, R.G. Morphine injections into the periaqueductal-periventricular gray attenuate septal hyperreactivity. Psychopharmacology 70, 113–114 (1980). https://doi.org/10.1007/BF00432380
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DOI: https://doi.org/10.1007/BF00432380