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Psychopharmacology

, Volume 70, Issue 1, pp 79–82 | Cite as

Flurazepam effects on methylphenidate-induced stereotyped behavior

  • Craig Risch
  • Daniel Kripke
  • David Janowsky
Original Investigations

Abstract

The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and night-time experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of methylphenidate (25 mg/kg and 50 mg/kg) increased locomotion and sniffing behavior. Flurazepam 3.0 mg/kg augmented methylphenidate-induced stereotyped gnawing behavior and stereotypy. Flurazepam significantly decreased locomotion and sniffing, but did not interact with methylphenidate's effects on locomotion and sniffing.

Key words

Methylphenidate Flurazepam Stereotyped behavior Dopamine Gnawing behavior Drug interaction 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Craig Risch
    • 1
  • Daniel Kripke
    • 1
  • David Janowsky
    • 1
  1. 1.Department of Psychiatry (M-003)University of California at San Diego, Medical SchoolLa JollaUSA

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