Summary
Muscle changes were studied in biopsy material obtained from 100 patients suffering from classical rheumatoid arthritis. The abnormalities consisted of denervation atrophy of type II muscle fibres, degenerative changes in the sarcoplasm including presence of nemaline rods, and changes within the interstitium: namely perivascular nodular myositis, lymphocytic accumulations, different stages of vasculitis and abnormalities within the intramuscular nerves and muscle spindles. The muscles examined were always severely affected. It is considered that the simultaneous presence of these abnormalities is suggestive of rheumatoid arthritis. The importance of histochemical studies is emphasized. The literature concerning muscle changes in rheumatoid arthritis is reviewed.
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References
Adams, R.D.: Nemaline rod myopathy. In: Disease of muscle. 3d ed., p. 247. New York: Harper and Row Publishers 1975
Beneke, G.: Die Reaktion des Muskelbindegewebes bei rheumatischen Erkrankungen. Verh. Dtsch. Ges. Rheumat. 2, 142–163 (1972)
Bethlem, J.: Muscle pathology. Amsterdam-London: North-Holland Publishing Company 1970
Cape, C.A., Johnson, W.W., Pitner, S.E.: Nemaline structures in polymyositis. Neurology (Minneap.) 20, 494–502 (1970)
Chamberlain, M.A., Bruckner, F.E.: Rheumatoid neuropathy: Clinical and electrophysiological features. Ann. rheum. Dis. 29, 609–616 (1970)
Cruickshank, B.: The arteritis in rheumatoid arthritis. Ann. rheum. Dis. 13, 136–146 (1954)
Curtis, A.C., Pollard, H.M.: Felty's syndrome: its several features including tissue changes, compared with other forms of rheumatoid arthritis. Ann. intern. Med. 13, 2265–2284 (1940)
De Forest, G.K., Bunting, H., Kenney, W.E.: Rheumatoid arthritis: The diagnostic significance of focal cellular accumulations in skeletal muscles. Amer. J. Med. 2, 40–44 (1947)
Engel, A.G.: Late-onset rod myopathy (a new syndrome?): Light and electron microscopic observations in two cases. Proc. Mayo Clin. 41, 713–741 (1966)
Engel, W.K.: A critique of congenital myopathies and other disorders. In: Milhorat, A.T. (ed.), Exploratory concepts in muscular dystrophy and related disorders, pp. 27–40. Amsterdam: Philadelphia: Lea and Febiger 1966
Fassbender, H.G.: Pathologie und Pathogenese der GefÄ\prozesse bei chronischer Polyarthritis. Verh. Dtsch. Ges. Rheumat. 4, 306–310 (1976)
Hartmann, F.: Differenzierung der chronischen Polyarthritis. Z. Rheumaforsch. 24, 161–179 (1965)
Haslock, D.I., Wright, V., Harriman, D.G.F.: Neuromuscular disorders in rheumatoid arthritis: A motorpoint muscle biopsy study. Quart. J. Med. 39, 335–358 (1970)
Hollander, L.J.: Arthritis and allied conditions. A textbook of rheumatology, 7th ed., p. 196. Philadelphia: Lea and Febiger 1966
Jerusalem, F., Goetze, H., Mumenthaler, M.: Zur diagnostischen SpezifizitÄt von nemaline Strukturen. Z. Neurol. 200, 148–157 (1971)
Kulka, J.P.: Vascular derangement in rheumatoid arthritis. In: Modern trends in rheumatology, 1st ed., pp. 49–69, edit. by Hill, A.G.S. London: Butterworth 1966
Magyar, é., Talerman, A., Fehér, M., Wouters, H.W.: Plasma cell myositis in rheumatoid arthritis. Acta med. Acad. Sci. hung. 31, 95–98 (1974)
Magyar, é., Talerman, A., Wouters, H.W.: Histological abnormalities in the muscle spindles in rheumatoid arthritis. Ann. rheum. Dis. 32, 143–150 (1973)
Morrison, L.R., Short, C.L., Ludwig, A.O., Schwab, R.S.: The neuromuscular system in rheumatoid arthritis. Amer. J. med. Sci. 214, 33–49 (1947)
Paget, J.: The clinical methods on the nervous mimicry of organic diseases. Lancet 1873 II, 727–729
Radnai, B.: Vascular changes in peripheral nerves and skeletal muscles in rheumatoid arthritis. Acta morph. Acad. Sci. hung. 3, 87–100 (1953)
Radnai, B.: Comparative morphology of small vessel lesions in rheumatoid arthritis and periarteritis nodosa. Acta morph. Acad. Sci. hung. 17, 69–79 (1969)
Rewcastle, N.B., Humphrey, J.G.: Vacuolar myopathy. Arch. Neurol. (Chic.) 12, 570–582 (1965)
Ropes, M.W., Bennet, G.A., Cobbs, S., Jacox, R., Jessar, R.A.: Revision of diagnostic criteria for rheumatoid arthritis. Bull. rheum. Dis. 9, 175–176 (1958)
Sokoloff, D., Wilens, S.L., Bunim, J.J., McEwen, C.: Diagnostic value of histological lesions of striated muscle in rheumatoid arthritis. Amer. J. med. Sci. 219, 174–182 (1950)
Steiner, G., Freund, H.A., Leichtentritt, B., Maun, M.E.: Lesions of skeletal muscles in rheumatoid arthritis (nodular polymyositis). Amer. J. Path. 22, 103–145 (1946)
Yates, D.A.: Muscular changes in rheumatoid arthritis. Ann. rheum. Dis. 22, 342–347 (1963)
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Temporary Research Fellow the Rotterdam Centre for Rheumatic Disease
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Magyar, é., Talerman, A., Mohácsy, J. et al. Muscle changes in rheumatoid arthritis. Virchows Arch. A Path. Anat. and Histol. 373, 267–278 (1977). https://doi.org/10.1007/BF00432241
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DOI: https://doi.org/10.1007/BF00432241