Abstract
The effects of hashish extract on adaptive behavior of male mice were studied in a paradigm which allows the investigation of learning mechanisms in a social context. Mice of the C3H strain, which were not submissive in a confrontation with a nonaggressive DBA mouse on day 1, were defeated on day 2 over 3 min by aggressive, isolated DBA mice, and showed conditioned submissive behavior upon mere contact with a nonaggressive DBA mouse on day 3. A hashish extract containing 38.6–39.4% Δ 9-tetrahydrocannabinol (Δ 9-THC), 11.6–12.0% cannabinol and 47.7–48.5% cannabidiol was administered orally in all experiments. Hashish extract given 90 min before defeat on day 2, in dosages corresponding to 1, 5, and 10 mg Δ 9-THC/kg, impaired retention of defensive upright, defensive sideways and immobility on day 3 (experiment 1). Experiment 2 showed that the drug (5, and 10 mg Δ 9-THC/kg) had no antinociceptive potency in mice and did not modify defeat-induced analgesia. Experiment 3, with drug (5 mg Δ 9-THC/kg) or solvent administration on day 2 and day 3, showed that the retention deficit was neither due to state-dependent learning, nor to impaired retrieval. It is suggested that hashish extract administered before learning may interfere with memory processing.
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References
Barry H, Kubena RK (1971) Repeated high doses of Δ 9-tetrahydrocannabinol enhance acquisition of shock avoidance by rats. Am Psychol Assoc Proc 79:747–748
Bueno OFA, Carlini EA (1972) Dissociation of learning in marihuana tolerant rats. Psychopharmacologia 25:49–56
Chesher GB, Dahl CJ, Everingham M, Jackson DM, Marchant-Williams H, Starmer GA (1973) The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice. Br J Pharmacol 49:588–594
Clark WC, Goetz RR, McCarthy RH, Bemproad B, Zeidenberg P (1979) Effects of marihuana on pain and verbal memory: A sensory decision theory analysis. In: Nahas GG, Paton WDM (eds) Marihuana: Biological effects. Adv Biosci: 22, 23, Pergamon, New York, pp 665–680
Cutler MG, Mackintosh JH, Chance MRA (1975) Effects of cannabis resin on social behavior in the laboratory mouse. Psychopharmacology 41:271–276
Darley LF, Tinklenberg JR, Roth WT, Hollister LE, Atkinson RC (1973) Influence of marihuana on storage and retrieval processes in memory. Memory and Cognition 1:196–200
Dornbush RL, Kokkevi A (1976) Acute effects of cannabis on cognitive, perceptual and motor performance in chronic hashish users. In: Dornbush RL, Freedman AM, Fink M (eds) Chronic cannabis use. Ann NY Acad Sci, vol 282. New York Academy of Sciences, New York, pp 313–322
Eddy NB, Leimbach D (1953) Synthetic analgesics II. Dithienylbutenyl-and dithienylbutylamines. J Pharmacol Exp Ther 107:385–393
Frischknecht HR, Siegfried B, Waser PG (1982) Learning of submissive behavior in mice: A new model. Behav Processes 7:235–245
Glick SD, Milloy S (1972) Tolerance, state-dependency and longterm behavioral effects of Δ 9-THC. In: Lewis MF (ed) Current research in marihuana. Academic Press, New York, pp 1–24
Goldberg ME, Hefner MA, Robichaud RC, Dubinsky B (1973) Effects of Δ 9-tetrahydrocannabinol (THC) and chlordiazepoxide (CDP) on state dependent learning: Evidence for asymmetrical dissociation. Psychopharmacologia 30:173–184
Grant EC, Mackintosh JH (1963) A comparison of the social postures of some laboratory rodents. Behaviour 21:246–257
Henriksson BG, Järbe TUC (1971) Effect of two tetrahydrocannabinols (Δ 9-THC and Δ 8-THC) on conditioned avoidance learning in rats and its transfer to normal state condition. Psychopharmacologia 22:23–45
Herring B (1972) The effect of 1-Δ 1-trans-tetrahydrocannabinol on learning and retention of avoidance performance in rats. Psychopharmacologia 26:401–406
Hill SY, Schwin R, Powell B, Goodwin DW, (1973) State-dependent effects of marihuana on human memory. Nature 243:241–242
Klonoff H, Low M, Marcus A (1973) Neuropsychological effects of marihuana. Can Med Assoc J 108:150–156
Loftus EF (1980) Alcohol, marihuana and memory. Psychology Today 13:42–56
McMillan DE (1977) Behavioral pharmacology of the tetrahydrocannabinols. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology, vol 1. Academic Press New York, pp 1–34
Miller LL (1984) Marijuana: Acute effects on human memory. In: Agurell S, Dewey RE, Willette RE (eds) The cannabinoids: Chemical, pharmacologic and therapeutic aspects. Academic Press, Orlando, pp 21–46
Miller LL, Cornett TL, Brightwell DR, McFarland DJ (1977) Marijuana: Effects on storage and retrieval of prose material. Psychopharmacology 51:311–316
Miller LL, Drew WG (1974) Cannabis: Review of behavioral effects in animals. Psychol Bull 81:401–417
Overton DA (1968) Dissociated learning in drug states (state dependent learning). In: Efron DM (ed) Psychopharmacology: A review of progress. US Government Printing Office, Washington, pp 918–930
Sieber B, Frischknecht HR, Waser PG (1980) Behavioral effects of hashish in mice: I. Social interactions and nest building behavior of males. Psychopharmacology 70:149–154
Sieber B, Frischknecht HR, Waser PG (1982) Behavioural effects of hashish in mice in comparison with other psychoactive drugs. Gen Pharmacol 13:315–320
Siegfried B, Frischknecht HR, Waser PG (1982) A new learning model for submissive behavior in mice: Effects of naloxone. Aggressive Behav 8:112–115
Siegfried B, Frischknecht HR, Waser PG (1984) Vasopressin impairs or enhances retention of learned submissive behavior in mice depending on the time of application. Behav Brain Res 11:259–269
Sofia RD, Vassar HB, Knobloch LC (1975) Comparative analgesic activity of various naturally occurring cannabinoids in mice and rats. Psychopharmacologia 40:285–295
Tinklenberg JR, Melges FT, Hollister LE, Gillespie HK (1970) Marijuana and immediate memory. Nature 226:1171–1172
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Frischknecht, H.R., Siegfried, B., Schiller, M. et al. Hashish extract impairs retention of defeat-induced submissive behavior in mice. Psychopharmacology 86, 270–273 (1985). https://doi.org/10.1007/BF00432212
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DOI: https://doi.org/10.1007/BF00432212