Abstract
Rats were lesioned unilaterally in the substantia nigra with 6-hydroxydopamine. Turning in response to apomorphine and amphetamine was assessed before and 5 days after 3-week treatment with haloperidol. After haloperidol withdrawal, contralateral turning, measured at 5 min following IP injection of 1 mg/kg apomorphine, was significantly less than before haloperidol treatment and ipsilateral turning, measured at 30 min following IP injection of 2 mg/kg amphetamine, was significantly greater than before the haloperidol treatment. These results suggest that dopamine receptor sensitivity increased on the unlesioned side compared to the lesioned side.
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Siever, L., Cohen, R. & Pert, A. Assessing pharmacologically induced dopamine receptor sensitivity changes with the ungerstedt turning model. Psychopharmacology 75, 212–213 (1981). https://doi.org/10.1007/BF00432190
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DOI: https://doi.org/10.1007/BF00432190