Abstract
Two groups of rats were trained in a CER paradigm. The conditioned stimulus was a sound, the unconditioned stimulus was an electric shock. Group 1 received conventional CER training before the effects of different doses of diazepam were studied. For Group 2 the shock was always and exclusively given contingent on pretreatment with diazepam. After prolonged training the compound thus became a discriminative stimulus complex (DSC) and produced response suppression during the CS. Group 2 was also challenged with various doses of diazepam. The results showed that diazepam acquired diametrically different properties in the two groups. Group 1 exhibited disinhibitory effects and Group 2 suppressive effects, which may reflect anxiolytic and anxiogenic properties, respectively.
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References
Colpaert FC, Desmedt LKC, Janssen PAJ (1976a) Discriminative stimulus properties of benzodiazepines, barbiturates and pharmacologically related drugs: relation to some intrinsic and anticonvulsant effects. Eur J Pharmacol 37:113–123
Colpaert FC, Niemeegers CJE, Janssen PAJ (1976b) Theoretical and methodological considerations on drug discrimination learning. Psychopharmacologia 46:169–177
Dantzer R (1977) Behavioral effects of benzodiazepines. A review. Biobehav Rev 1:71–86
Estes WK, Skinner BF (1941) Some quantitative properties of anxiety. J Exp Psychol 29:390–400
Heistad GT, Torres AA (1959) A mechanism for the effect of a tranquilizing drug on learned emotional responses. Univ Minn Med Bull 30:518–527
Houser VP (1978) The effects of drugs on behavior controlled by aversive stimuli. In: Blackman DE, Sanger DJ (eds) Contemporary research in behavioral pharmacology. Plenum, New York, pp 69–157
Overton DA (1973) State-dependent learning produced by addicting drugs. In: Freeman AM, Fisher S (eds) Opiate addiction: Origins and treatment. Winston, Washington DC, pp 61–75
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Haug, T., Götestam, K.G. Two opposite effects of diazepam on fear by differential training in the CER-paradigm. Psychopharmacology 75, 110–113 (1981). https://doi.org/10.1007/BF00432170
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DOI: https://doi.org/10.1007/BF00432170