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Intracranial self-stimulation in mice using a modified hole-board task: Effects of d-amphetamine

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Abstract

Mice implanted with stimulating electrodes in the lateral hypothalamus demonstrated reliable selfstimulation rates when given the opportunity to break a photobeam in a modified hole-board task. Selfstimulation rates were enhanced by low dosages of d-amphetamine but were depressed by high dosages. The dose-dependent effects of amphetamine could not be accounted for by changes in exploratory hole-board activity and were discussed in terms of an interaction between the rewarding properties of electrical brain stimulation and the reinforcing properties of amphetamine administration.

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Authors and Affiliations

  1. Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada

    Larry Kokkinidis

  2. Department of Psychology, University of Calgary, Calgary, Alberta, Canada

    Robert M. Zacharko

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  1. Larry Kokkinidis
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  2. Robert M. Zacharko
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Kokkinidis, L., Zacharko, R.M. Intracranial self-stimulation in mice using a modified hole-board task: Effects of d-amphetamine. Psychopharmacology 68, 169–171 (1980). https://doi.org/10.1007/BF00432136

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  • DOI: https://doi.org/10.1007/BF00432136

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