Red blood cell anti-oxidant parameters in silicosis

  • P. J. A. Borm
  • A. Baste
  • E. F. M. Wouters
  • J. J. Slangen
  • G. M. H. Swaen
  • Tj. de Boorder


The anti-oxidant phenotype was determined in red blood cells and plasma of a group of male control subjects (n = 48) and a number of silicosis patients (n = 19). Haemoglobin, reduced and oxidized glutathione, glutathione peroxidase and superoxide dismutase were determined in red blood cells after haemolysis. In plasma, water soluble fluorescent substances were determined as a measure of in vivo lipid peroxidation. A significant increase in red blood cell glutathione was observed in silicosis patients. Moreover, some factors of the anti-oxidant system are strongly correlated in the diseased, but not in the healthy subjects. We hypothesize that individual susceptibility differences towards the development of silicosis after prolonged inhalation of silica is associated with a genetically controlled antioxidant phenotype.

Key words

Silicosis Anti-oxidant system Erythrocytes SOD 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • P. J. A. Borm
    • 1
  • A. Baste
    • 2
  • E. F. M. Wouters
    • 3
  • J. J. Slangen
    • 1
  • G. M. H. Swaen
    • 1
  • Tj. de Boorder
    • 1
  1. 1.Department of Occupational MedicineState University of LimburgMaastrichtThe Netherlands
  2. 2.Department of PharmacochemistryFree University AmsterdamAmsterdamThe Netherlands
  3. 3.Department of PulmonologyState University of LimburgMaastricht

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