Abstract
A Geller-Seifter paradigm for discerning anxiolytic and ataxic effects of drugs was used to study the interactions between low doses of ethanol and cocaine. Ethanol produced significant anxiolytic and ataxic effects at a dose of 1 g/kg. Cocaine at a dose as low as 10 mg/kg markedly antagonized the anxiolytic effect of ethanol, but simultaneously augmented ethanol's ataxic effects, as measured by response rates during a random-interval schedule. These results indicate that ethanol may interact to a significant degree with brain aminergic systems and that, contrary to popular dogma, stimulants may reverse some components of ethanol intoxication, but increase ethanol's debilitating motor effects.
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References
Aston-Jones G, Foote SL, Bloom FE (1982) Low doses of ethanol disrupt sensory responses of brain norepinephrine neurons. Nature 296:857–860
Barry H (1977) Alcohol. In: Pradhan SN, Dutta, SM (eds) Drug abuse: Clinical and basic aspects. Mosby, Saint Louis
Geller I, Seifter J (1960) The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in rat. Psychopharmacologia 1:482–492
Glowa JR, Barrett, JE (1976) Effects of alcohol on punished and unpunished responding of squirrel monkeys. Pharmacol Biochem Behav 4:169–173
Jeffrey DR, Barrett JE (1979) Effects of chlordiazepoxide on comparable rates of punished and unpunished responding. Psychopharmacology 64:9–11
McKearny JW, Barrett JE (1978) Schedule-controlled behavior and the effects of drugs. In: Blackman DE, Sanger DJ (eds) Contemporary research in behavioral pharmacology. Plenum, New York, pp 1–68
Pollard GT, Howard JL (1979) The Geller-Seifter conflict paradigm with incremental shock. Psychopharmacology 62:117–121
Rech RH, Vomachka MK, Rickert D, Braude MC (1976) Interactions between amphetamine and alcohol and their effect on rodent behavior. Ann NY Acad Sci 281:426–440
Redmond DE (1979) New and old evidence for the involvement of a brain norepinephrine system in anxiety. In: Fann W, Karacan I, Porkorny A, Williams R (eds) Phenomenology and treatment of anxiety. Spectrum, New York, 153–203
Sepinwall J, Cook L (1979) Behavioral pharmacology of antianxiety drugs. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 13. Plenum, New York, pp 345–393
Stein L, Wise CD, Berger BD (1973) Antianxiety action of benzodiazepines: Decrease in activity of serotonin in the punishment system. In: Garattini S, Mussini E, Randall LO (eds) The benzodiazepines. Raven, New York, pp 299–326
Wallgren H, Barry III H (1970) Actions of alcohol. Elsevier, Amsterdam
Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York