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Effects of water temperature and weight of wheel load on water wheel turning behavior of imipramine administered mice

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Abstract

This experiment investigated the effect of imipramine on water wheel turning behavior in relation to the water temperature and the wheel load. It was shown that the higher the water temperature, the more the mice rotated the wheel, and the greater the wheel load, the less mice rotated it. However, these factors did not reduce the effect of imipramine, which increased the number of responses. It was suggested that the water wheel test shows promise as a screening test for antidepressants.

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Authors and Affiliations

  1. Department of Psychology, School of Hygiene, Kutsukake 1-98, 470-11, Toyoake, Aichi, Japan

    Jun Shimizu

  2. Department of Neuropsychiatry, School of Medicine, Fujita-Gakuen University, Kutsukake 1-98, 470-11, Toyoake, Aichi, Japan

    Soichiro Nomura, Hiroko Kuno & Tsuneyuki Nakazawa

Authors
  1. Jun Shimizu
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  2. Soichiro Nomura
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  3. Hiroko Kuno
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  4. Tsuneyuki Nakazawa
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Shimizu, J., Nomura, S., Kuno, H. et al. Effects of water temperature and weight of wheel load on water wheel turning behavior of imipramine administered mice. Psychopharmacology 84, 20–21 (1984). https://doi.org/10.1007/BF00432017

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  • DOI: https://doi.org/10.1007/BF00432017

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