, Volume 84, Issue 1, pp 12–15 | Cite as

The opiate quasiwithdrawal syndrome in rhesus monkeys: Comparison of naloxone-precipitated withdrawal to effects of cholinergic agents

  • Jonathan L. Katz
  • Rita J. Valentino
Original Investigations


The effects of the cholinergic agents UM-1046 (3-cyclopropyl-methyl-1,2,3,4,5,6-hexahydro-8-hydroxy-6-methyl-3-benzazocine hydrochloride) and physostigmine in normal rhesus monkeys were compared to naloxone-precipitated withdrawal in morphine-dependent subjects. The two cholinergic drugs produced effects that resembled one another, as well as some of the effects of naloxone in morphine-dependent subjects. The constellation of signs produced by the cholinergic drugs, while overlapping, was not identical to that produced by naloxone in opiate-dependent subjects. Although cholinergic agents produce many of the signs of opiate withdrawal, the withdrawal syndrome in its complete manifestation involves many different neurotransmitter systems.

Key words

Opiate dependence Opiate withdrawal Quasiwithdrawal syndrome Precipitated withdrawal Opiate antagonists UM-1046 Physostigmine Naloxone Acetylcholine release Rhesus monkeys 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Jonathan L. Katz
    • 1
  • Rita J. Valentino
    • 2
  1. 1.NIDA Addition Research CenterBaltimoreUSA
  2. 2.Department of PharmacologyGeorge Washington University Medical CenterWashington, DCUSA

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