Psychopharmacology

, Volume 67, Issue 2, pp 181–188 | Cite as

Modification of different morphine actions by 6-hydroxydopamine and 6-hydroxydopamine plus desmethylimipramine

  • V. Fuchs
  • H. Coper
Original Investigations

Abstract

After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly protected. The concentration of 5-hydroxytryptamine (5-HT) is not influenced by 6-OHDA or 6-OHDA +DMI. Chronic morphine treatment to some extent enhances reduced NA and DA levels after 6-OHDA, but the decreased central catecholamine (CA) content after 6-OHDA+DMI is not raised. Morphine analgesia is highly attenuated in 6-OHDA and 6-OHDA +DMI mice. the reduction occurs in nontolerant as well as in tolerant animals. The acute effect of morphine on body temperature is abolished with 6-OHDA, but not with 6-OHDA+DMI, whereas the interaction of central CA in morphine-induced running shows distinctly marked reduction with 6-OHDA +DMI, but not with 6-OHDA. Acute toxicity is enhanced by 6-OHDA+DMI whereas the development of tolerance against the toxicity of morphine is diminished by 6-OHDA. Lack of CA in the brain decreases sensitivity against naloxone withdrawal in acute as well as in chronic experiments.

Key words

Mice 6-OHDA 6-OHDA+DMI Morphine Analgesia Body temperature Motility Lethality Physical dependence 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • V. Fuchs
    • 1
  • H. Coper
    • 1
  1. 1.Institut für Neuropsychopharmakologie der Freien Universität BerlinBerlin 19

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