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Psychopharmacology

, Volume 62, Issue 3, pp 253–259 | Cite as

Feeding parameters with two food textures after chlordiazepoxide administration, alone or in combination with d-amphetamine or fenfluramine

  • Steven J. Cooper
  • Raymond L. Francis
Original Investigations

Abstract

Chlordiazepoxide (5.0, 10.0 mg/kg) reduced the rate of eating and extended the duration of feeding in a 10 min feeding test. It also reduced the latency to feed. Both fenfluramine (1.0 mg/kg) and d-amphetamine (0.25 mg/kg) acted to reduce food intake, but by differing mechanisms. Fenfluramine reduced eating rate without affecting eating duration, whilst d-amphetamine reduced eating duration without reducing eating rate. The effects of chlordiazepoxide on feeding parameters were generally additive with those of either d-amphetamine or fenfluramine, whenever chlordiazepoxide was given in combination with one of the anorectic drugs. Food texture affected feeding behaviour; rats ate standard diet in pellet form faster than powdered food, although they spent longer eating the powdered food. Textural differences did not significantly interact with the changes in feeding responses induced by the 3 drugs, except that latency to eat after either d-amphetamine or fenfluramine injection, when pellets were available, was significantly prolonged. Characterising drug effects on feeding in terms of a 2-dimensional matrix of eating rate and duration is recommended, rather than relying solely on amount of food consumption as the measure of drug effects.

Key words

d-Amphetamine Drug combinations Chlordiazepoxide Eating duration Eating rate Fenfluramine Food texture 

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References

  1. Abdallah, A. H., White, H. D., Kulkarni, A. S.: Interaction of d-amphetamine with central nervous system depressants on food intake and spontaneous motor activity of mice. Eur. J. Pharmacol. 26, 119–121 (1974)Google Scholar
  2. Bainbridge, J. G.: The effect of psychotropic drugs on food reinforced behaviour and on food consumption. Psychopharmacologia (Berl) 12, 204–213 (1968)Google Scholar
  3. Barrett, A. M., McSharry, L.: Inhibition of drug-induced anorexia in rats by methysergide. J. Pharm. Pharmacol. 27, 889–895 (1975)Google Scholar
  4. Blundell, J. E., Latham, C. J., Leshem, M. N.: Differences between the anorexic actions of amphetamine and fenfluramine —possible effects on hunger and satiety. J. Pharm. Pharmacol. 28, 471–477 (1976)Google Scholar
  5. Borella, L. E., Paquette, R., Herr, F.: The effect of some CNS depressants on the hypermotility and anorexia induced by amphetamine in rats. Can. J. Physiol. Pharmacol. 47, 841–847 (1969)Google Scholar
  6. Brown, R. F., Houpt, K. A., Schryver, H. F.: Stimulation of food intake in horses by diazepam and promazine. Pharmacol. Biochem. Behav. 5, 485–497 (1976)Google Scholar
  7. File, S. E., Vellucci, S. V.: Studies on the role of ACTH and of 5-HT in anxiety, using an animal model. J. Pharm. Pharmacol. 30, 105–110 (1978)Google Scholar
  8. Fratta, W., Mereu, G., Chessa, P., Paglietti, E., Gessa, G.: Benzodiazepine-induced voraciousness in cats and inhibition of amphetamine-anorexia. Life Sci. 18, 1157–1166 (1976)Google Scholar
  9. Jespersen, S., Scheel-Krüger, J.: Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia. J. Pharm. Pharmacol. 25, 49–54 (1973)Google Scholar
  10. Laduron, P. M., Janssen, P. F. M., Leysen, J. E.: Spiperone: a ligand of choice for neuroleptic receptors. 3. Subcellular distribution of various neuroleptic drugs and their receptors in various rat brain areas. Biochem. Pharmacol. 27, 323–328 (1978)Google Scholar
  11. Leibowitz, S. F.: Identification of catecholamine receptor mechanisms in the perifornical lateral hypothalamus and their role in mediating amphetamine and L-dopa anorexia. In: Central mechanisms of anorectic drugs, S. Garattini and R. Samanin, eds., pp. 39–82. New York: Raven Press 1978Google Scholar
  12. Leysen, J. E., Gommeren, W., Laduron, P. M.: Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding. Biochem. Pharmacol. 27, 307–316 (1978)Google Scholar
  13. McGuigan, M.: Unpublished B. Sc. thesis. Queen's University, Belfast (1978)Google Scholar
  14. Mereu, G. P., Fratta, W., Chessa, P., Gessa, G. L.: Voraciousness induced in cats by benzodiazepines. Psychopharmacology 47, 101–103 (1976)Google Scholar
  15. Poschel, B. P. H.: A simple and specific screen for benzodiazepine-like drugs. Psychopharmacologia (Berl.) 19, 193–198 (1971)Google Scholar
  16. Randall, L. O., Schallek, W., Heise, G. A., Keith, E. F., Bagdon, R. E.: The psychosedative properties of methaminodiazepoxide. J. Pharmacol. Exp. Ther. 129, 163–171 (1960)Google Scholar
  17. Soubrié, P., Kulkarni, S., Simon, P., Boissier, J.R.: Effets des anxiolytiques sur la prise de nourriture de rats et de souris placés en situation nouvelle ou familière. Psychopharmacologia (Berl.) 45, 203–210 (1975)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Steven J. Cooper
    • 1
  • Raymond L. Francis
    • 1
  1. 1.Department of PsychologyThe Queen's University of BelfastNorthern Ireland

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