Psychopharmacology

, Volume 77, Issue 2, pp 156–158 | Cite as

Stimulant actions of histamine H1 antagonists on operant behavior in the squirrel monkey

  • James W. McKearney
Original Investigations

Abstract

Squirrel monkeys were studied under fixed-interval schedules of reinforcement in which the first response (lever press) after a fixed period of time resulted either in the delivery of a food pellet or in the termination of stimuli associated with impending electric shock delivery. Benztropine mesylate (0.03–1.7 mg/kg), promethazine HCl (0.3–10 mg/kg), and diphenhydramine HCl (0.3–17 mg/kg) all produced marked increases in responding at intermediate doses. The increases in responding were at least as great as those observed with psychomotor stimulants, such as amphetamine, in this species under similar behavioral conditions. Benztropine was most potent and diphenhydramine was least potent in most monkeys and, in some, promethazine and diphenhydramine were about equipotent. The order of potency and the magnitude of potency differences among the drugs suggest that the behavioral effects were due to antagonist actions at histamine H1 receptors, rather than to effects on dopamine uptake or on muscarinic receptors.

Key words

Benztropine Promethazine Diphenhydramine Antihistamines Histamine Operant behavior Squirrel monkey 

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References

  1. Douglas WW (1980) Histamine and 5-hydroxytryptamine (serotonin) and their antagonists. In: Gilman AF, Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 609–646Google Scholar
  2. Goldberg SE (1980) Histamine as a punisher in squirrel monkeys: Effects of pentobarbital, chlordiazepoxide and H1- and H2-receptor antagonists on behavior and cardiovascular responses. J Pharmacol Exp Ther 214, 726–736Google Scholar
  3. Horn AS, Coyle JT, Snyder SH (1971) Catecholamine uptake by synaptosomes from rat brain: Structure-activity relationships of drugs with different effects on dopamine and norepinephrine neurons. Mol Pharmacol 7, 66–80Google Scholar
  4. McKearney JW (1974) Effects of d-amphetamine, morphine, and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation. J Pharmacol Exp Ther 191, 141–153Google Scholar
  5. McKearney JW (1981) Individual differences in effects of tricyclic antidepressants and anticholinergic drugs on operant behavior in the squirrel monkey. Life Sci 28, 2049–2054Google Scholar
  6. Richelson E (1981) Tricyclic antidepressants: Interactions with histamine and muscarinic cholinergic receptors. In: Enna SJ, Malick JB, Richelson E (eds) Antidepressants: Neurochemical, behavioral, and clinical perspectives. Raven, New York, pp 53–73Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • James W. McKearney
    • 1
  1. 1.Worcester Foundation for Experimental BiologyShrewsburyUSA

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