Psychopharmacology

, Volume 77, Issue 2, pp 117–123 | Cite as

Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats

  • Alexander Stiglick
  • Harold Kalant
Original Investigations

Abstract

Chronic oral administration of cannabis extract to rats (daily Δ9tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radialarm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6 months (Experiment I) or 3 months (Experiment II) with the drug. In Experiment III, animals that received the extract for 3 months exhibited significant learning deficits on a much more difficult 12-arm radial maze. The results demonstrate that the deleterious effects of cannabis on radial-arm maze learning are probably due to a tendency toward increased vigilance and perseveration, possibly combined with an impaired utilization of spatial cues.

Key words

Chronic cannabis Learning Radial-arm maze Rat 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Alexander Stiglick
    • 1
    • 2
  • Harold Kalant
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of TorontoTorontoCanada
  2. 2.Addiction Research Foundation of OntarioTorontoCanada

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