Psychopharmacology

, Volume 56, Issue 2, pp 191–193 | Cite as

GABA involvement in memory consolidation: Evidence from posttrial amino-oxyacetic acid

  • R. J. Katz
  • L. Liebler
Article

Abstract

In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning within sessions and a lack of consolidation across sessions. Controls, on the other hand, showed learning both within and across sessions. This evidence agrees with previous reports suggesting GABA involvement in memory processes.

Key words

AOAA Consolidation GABA Memory 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • R. J. Katz
    • 1
  • L. Liebler
    • 1
  1. 1.Mental Health Research Institute, Department of PsychiatryUniversity of Michigan Medical CenterAnn ArborUSA

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