Central muscarinic receptors and male rat sexual behavior: Facilitation by oxotremorine but not arecoline or pilocarpine in methscopolamine pretreated animals
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Oxotremorine (0.1–0.8 mg/kg IP), but not arecoline (12–48 mg/kg IP), or pilocarpine (5–20 mg/kg IP), reduced both the number of intromissions to ejaculation and the ejaculation latency in methscopolamine-pretreated male rats. The effects of oxotremorine, (0.4 mg/kg IP) were completely antagonized by the administration of scopolamine (0.4 mg/kg IP). Methscopolamine (3–12 mg/kg IP), or scopolamine (0.2–0.4 mg/kg IP) did not by themselves produce any statistically significant effects on male rat sexual behavior.
Key wordsSexual behavior CNS Muscarinic receptors Male rat
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