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Psychopharmacology

, Volume 51, Issue 2, pp 185–187 | Cite as

Lack of effect of tricyclic antidepressants on serum prolactin levels

  • Herbert Y. Meltzer
  • Songkait Piyakalmala
  • Paul Schyve
  • Victor S. Fang
Human Pharmacology

Abstract

A previous report indicated that the tricyclic antidepressants imipramine and amitriptyline markedly increased plasma prolactin levels in man. We found no increases after acute or chronic treatment with either drug in usual clinical doses. The results indicate that blockade of serotonin reuptake does not affect basal prolactin levels in man.

Key words

Prolactin Tricyclic antidepressants Amitriptyline Imipramine 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Herbert Y. Meltzer
    • 1
    • 2
  • Songkait Piyakalmala
    • 1
    • 2
  • Paul Schyve
    • 1
    • 2
  • Victor S. Fang
    • 1
    • 2
  1. 1.Department of Psychiatry and MedicineUniversity of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Illinois State Psychiatric InstituteChicagoUSA

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