Abstract
The behavioral effects of R-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane or BL-3912A were compared with those of S-Amphetamine and R-DOM. BL-3912A facilitated acquisition of shuttle box responding by rats without increasing noncontingent intertrial (ITI) activity, while S-Amphetamine increased both avoidance and ITI responding. R-DOM had a biphasic effect on avoidance responding, increasing it at low doses and disrupting at higher doses. At doses that facilitated shuttle box responding, BL-3912A had no effect on unacclimated motor activity of rats nor on the rate of continuous avoidance responding by rats. S-Amphetamine increased the frequency of both motor activity and operant avoidance responding, while R-DOM decreased motor activity and increased operant avoidance responding. By facilitating avoidance behavior without increasing other measures of psychomotor activity, BL-3912A represents a unique psychopharmacological agent clearly different from R-DOM and S-Amphetamine.
Similar content being viewed by others
References
Beaton, J. M., Smythies, J., Benington, F., Morin, R.: The behavioral effects of 2,5-dimethoxy-4-methyl amphetamine (DOM) in rats. Res. Comm. Behav. Biol. 3, 81–84 (1969)
Buyniski, J. P., Smith, M. L., Bierwagen, M. E.: Cardiovascular and gross behavioral effects of amphetamine, 2-amino-1-(2,5-dimethoxy-4-methylphenyl) propane (DOM) and 2-amino-1-(2,5-dimethoxy-4-methylphenyl)butane (BL-3912A) in the conscious dog. Res. Comm. Chem. Path. Pharmacol. 8, 213–221 (1974)
Hayes, W.: Statistics for psychologists. New York: Holt, Rinehart and Winston 1965
Honecker, H., Coper, H.: Kinetics and metabolism of amphetamine in the brain of rats of different ages. Naunyn-Schmiedeberg's Arch. Pharmacol. 291, 111–121 (1975)
Marquis, W. J., Tilson, H. A., Rech, R. H.: Effects of amphetamine, LSD, psilocybin and DOM on schedule-controlled behavior in the rat. Fed. Proc. 32, 818 (1973)
Snyder, S., Faillace, L., Weingartner, H.: DOM (STP), a new hallucinogenic drug and DOET: effects in normal subjects. Amer. J. Psychiat. 125, 357–364 (1968)
Snyder, S., Weingartner, H., Faillace, L.: DOET (2,5-dimethoxy-4-ethylamphetamine) and DOM (STP) (2,5-dimethoxy-4-methylamphetamine), new psychotropic agents: their effects in man. In: Psychotomimetic drugs, D. Efron, ed., pp. 247–263. New York: Raven Press 1970
Standridge, R., Howell, H., Gylys, J. A., Partyka, R. A., Shulgin, A.: Phenylalkylamines with potential psychotherapeutic utility. I. 2-amino-1-(2,5-dimethoxy-4-methylphenyl)butane. J. med. Chem. (in press, 1976)
Tilson, H. A., Baker, T. G., Chamberlain, J. H., Marquis, W. J., Rech, R. H.: Behavioral and neuropharmacological analysis of 2,5-dimethoxy-4-methyl-amphetamine (DOM) and amphetamine in rats. Psychopharmacologia (Berl.) 44, 229–239 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tilson, H.A., Chamberlain, J.H. & Gylys, J.A. Behavioral comparisons of R-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) with R-DOM and S-Amphetamine. Psychopharmacology 51, 169–173 (1977). https://doi.org/10.1007/BF00431735
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00431735