, Volume 51, Issue 2, pp 125–127 | Cite as

Cocaine effects on sleep parameters in the rat

  • Shirley Y. Hill
  • Wallace B. Mendelson
  • David A. Bernstein
Animal Studies


Cocaine in 6 mg/kg doses was administered orally and intraperitoneally to rats and sleep EEG's recorded. Cocaine significantly reduced total sleep time, slow-wave sleep, and sleep latency. Rapid eye movement sleep (REM) was significantly suppressed during the first half of the sleep recording. These effects were evident by both routes of administration. The effects of cocaine on total sleep time in animals parallels that observed in man.

Key words

Cocaine Stimulants Sleep Oral administration Encephalograph 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Shirley Y. Hill
    • 1
  • Wallace B. Mendelson
    • 1
  • David A. Bernstein
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. Louis

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