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Psychopharmacology

, Volume 51, Issue 2, pp 125–127 | Cite as

Cocaine effects on sleep parameters in the rat

  • Shirley Y. Hill
  • Wallace B. Mendelson
  • David A. Bernstein
Animal Studies

Abstract

Cocaine in 6 mg/kg doses was administered orally and intraperitoneally to rats and sleep EEG's recorded. Cocaine significantly reduced total sleep time, slow-wave sleep, and sleep latency. Rapid eye movement sleep (REM) was significantly suppressed during the first half of the sleep recording. These effects were evident by both routes of administration. The effects of cocaine on total sleep time in animals parallels that observed in man.

Key words

Cocaine Stimulants Sleep Oral administration Encephalograph 

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References

  1. Downs, A. W., Eddy, N. B.: The effect of repeated doses of cocaine on the rat. J. Pharmacol. exp. Ther. 46, 199–200 (1932Google Scholar
  2. Hill, S. Y., Powell, B. J.: Cocaine and morphine self-administration: Effects of differential rearing. (In press)Google Scholar
  3. Jatlow, P. I., Bailey, D. N.: Gas-chromatographic analysis for cocaine in human plasma, with use of a nitrogen detector. Clin. Chem. 21, 1918–1921 (1975)Google Scholar
  4. Mendelson, W. B., Guthrie, R. D., Frederick, G. Wyatt, R. J.: The flower pot technique of rapid eye movement (REM) sleep deprivation. Pharmacol. Biochem. Behav. 2, 553–556 (1974)Google Scholar
  5. Moore, J. M.: Gas chromatographic detection of ecgonine and benzoylecgonine in cocaine. J. Chromatogr. 101, 215–218 (1974)Google Scholar
  6. Morden, B., Mitchell, G., Dement, W.: Selective REM sleep deprivation and compensation phenomena in the rat. Brain Res. 5, 339–349 (1967)Google Scholar
  7. Morpugo, C.: Drug-induced modifications of discriminated avoidance behavior in rats. Psychopharmacologia (Berl.) 8, 91–99 (1965)Google Scholar
  8. Oswald, I.: Sleep and dependence on amphetamine and other drugs. In: Sleep: physiology and pathology, A. Kales, ed., pp. 317–330. Philadelphia: Lippincott 1969Google Scholar
  9. Oswald, I.: Effects on sleep of amphetamine and its derivatives. In: Amphetamines and related compounds. Proceedings of the Mario Negri Institute for Pharmacological Research, Milan, Italy. E. Costa and S. Garattini, eds., pp. 865–871. New York: Raven Press 1970Google Scholar
  10. Post, R. M., Gillin, J. C., Wyatt, R. J., Goodwin, F. K.: The effect of orally administered cocaine on sleep of depressed patients. Psychopharmacologia (Berl.) 37, 59–66 (1974)Google Scholar
  11. Post, R. M., Kopanda, R. T.: Cocaine, kindling, and reverse tolerance. Lancet 1975, 409–410Google Scholar
  12. Rechtschaffen, A., Maron, L.: The effect of amphetamine on the sleep cycle. Electroecephalogr. Clin. Neurophysiol. 16, 438–455 (1964)Google Scholar
  13. Ritchie, J. M., Cohen, P. J., Dripps, R. D.: Cocaine; procaine and other synthetic local anesthetics. In: The pharmacological basis of therapeutics. L. S. Goodman and A. Gilman, eds., pp. 371–401. London: MacMillan 1970Google Scholar
  14. Rose, C. L.: Studies in the pharmacology of local anesthetics. III. Comparison of gamma-(2-methyl piperidine) propyl benzoate hydrochloride with cocaine and procaine on experimental animals. J. Lab. clin. Med. 15, 731–735 (1930)Google Scholar
  15. Scheel-Krüger, J.: Behavioural and biochemical comparison of amphetamine derivatives, cocaine, benztropine and tricyclic anti-depressant drugs. Europ. J. Pharmacol. 18, 63–73 (1972)Google Scholar
  16. Tatum, A. L., Seevers, M. H.: Experimental cocaine addiction. J. Pharmacol. exp. Ther. 36, 401–410 (1929)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Shirley Y. Hill
    • 1
  • Wallace B. Mendelson
    • 1
  • David A. Bernstein
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. Louis

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