Abstract
In platelets of six volunteers taking chlorimipramine (50 mg/day) for 1 week, 5-HT levels were markedly decreased at the time of treatment withdrawal, and remained significantly reduced after a 1-week washout. Individual levels in five subjects remained affected during a 3-week washout.
The previously reported observations of reduced serotonin concentration in platelets from depressed patients may reflect a residual effect of previous antidepressant treatment.
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Poirier, M.F., Le Quan-Bui, KH., Lôo, H. et al. Changes in human platelet 5 HT level after 1 week of chlorimipramine treatment. Psychopharmacology 86, 194–196 (1985). https://doi.org/10.1007/BF00431708
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DOI: https://doi.org/10.1007/BF00431708