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Effects of d,l-propanolol on open field behavior of rats

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Abstract

Rats were administered with different doses of d,l-propranolol or d,l-propranolol plus amphetamine before open-field observations. Results show that d,l-propranolol decreased locomotion and rearing frequencies and increased immobility duration in rats. An antagonism between the effects of amphetamine and d,l-propranolol on general activity of rats was also observed. Results are discussed in the light of a possible interference of the drugs with the activity of either noradrenergic neurons or midbrain reticular formation.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of São Paulo, Av. Corifen de Azevedo Marques 2720, CEP 05340, Sao Paulo, Brazil

    A. Poli & J. Palermo-Neto

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  1. A. Poli
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  2. J. Palermo-Neto
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Poli, A., Palermo-Neto, J. Effects of d,l-propanolol on open field behavior of rats. Psychopharmacology 86, 153–155 (1985). https://doi.org/10.1007/BF00431701

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  • DOI: https://doi.org/10.1007/BF00431701

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