Biphasic and long-lasting effect of ceruletide on tardive dyskinesia
A 55-year-old schizophrenic inpatient with buccolingual dyskinesia was treated with a single dose of ceruletide 0.8 μg/kg IM. Time-course effects of the drug were then followed for up to 6 weeks after injection. To assess changes in severity of bucco-lingual dyskinesia objectively, electromyogram (EMG) and microvibration (MV) were recorded. Simultaneously, bucco-lingual dyskinesias were also evaluated by using a five-point rating scale. Before injection of ceruletide, severity of dyskinesia was “moderate” and 3–4 Hz of dyskinetic oral movements were dominant. “Extremely severe” and repetitious gross oral movements (around 1 Hz) were observed within a few minutes after injection and continued for up to 1 h. Thereafter, oral movements tended to decrease, and they disappeared completely 3 weeks after injection. This biphasic and long-lasting effect of ceruletide on tardive dyskinesia might contribute to further understanding of the physio-pathophysiological role of cholecystokinin-like peptides in the brain, and provide a basis for practical treatment of tardive dyskinesia.
Key wordsDyskinesia Ceruletide Dopamine
- Gerlach J, Reisby N, Randrup A (1974) Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia. Psychopharmacology 34:21–35Google Scholar
- Lundberg JM, Hökfelt T (1983) Coexistence of peptides and classical neurotransmitters. Trends Neurosci 6:325–333Google Scholar
- Moroji T, Watanabe N, Aoki N, Itoh S (1982) Antipsychotic effects of ceruletide (caerulein) on chronic schizophrenia. Arch Gen Psychiatry 39:485–486Google Scholar
- Nishikawa T, Tanaka M, Koga I, Uchida Y (1983) Combined treatment of tardive dyskinesia with clonidine and neuroleptics: a follow-up study of three cases for three years. Psychopharmacology 80:374–375Google Scholar
- Nishikawa T, Tanaka M, Tsuda A, Koga I, Uchida Y (1984) Clonidine therapy of tardive dyskinesia and the related syndromes. Clin Neuropharmacol 7:239–245Google Scholar