Abstract
Intraventricular administration of kainic acid at the dose of 0.1 μg induces a significant depression of rectal temperature followed rapidly by its slight elevation. Morphine (40.0 mg·kg-1 IP), which by itself elicited biphasic effect on the body temperature of rats—initially hypothermia followed by hyperthermia—slightly increased the kainic acid-induced hypothermia. Kainic acid did not cause any changes in the hyperthermic effect of low doses of morphine (10.0 mg·kg-1). Pretreatment of rats with nalorphine enhanced the kainic acid-induced hypothermia. On the contrary, nalorphine reversed the hypothermic effect produced by morphine at the dose of 40.0 mg·kg-1. The results suggest that morphine and kainic acid-induced hypothermia are not mediated by the influence on the same type of receptors.
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Turski, L., Turski, W., Czuczwar, S.J. et al. Effects of morphine and nalorphine on kainic acid-induced hypothermia in rats. Psychopharmacology 72, 211–214 (1981). https://doi.org/10.1007/BF00431659
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DOI: https://doi.org/10.1007/BF00431659