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Psychopharmacology

, Volume 72, Issue 2, pp 117–127 | Cite as

Cigarette smoking in rhesus monkeys

  • Kiyoshi Ando
  • Tomoji Yanagita
Original Investigations

Abstract

In the present pilot study, an attempt was made to shape and maintain cigarette smoking behavior in rhesus monkeys both with and without the simultaneous use of other reinforcers. Initially, 14 monkeys were trained to suck air and puff on cigarettes using sweetened liquid reinforcer. After smoking had been established, the sweetened liquid reinforcement was removed. Smoking without this reinforcement, referred to as ‘voluntary smoking,’ was then observed during 20-h daily sessions. Of 14 monkeys studied, 2 have engaged in voluntary smoking for 2 years or longer. The maximum figures recorded for any single 20-h session were 3,271 puffs (20 cigarettes) in one monkey and 16,384 puffs (47 cigarettes) in the other. Although the baseline variability of smoking by these monkeys was quite high, low-nicotine and nicotine-free cigarettes seemed to lead to clear decreases in smoking. In 2 other monkeys that did not perform voluntary smoking, smoking was reestablished under a randomtime or a tandem schedule for sweetened liquid reinforcement. Within this situation (‘schedule-controlled smoking’) schedule manipulations also led to changes in intake of cigarrette smoke. The voluntary smoking model described in the present paper should be useful for studying the factors involved in initiating and maintaining smoking behavior and for studying the psychopharmacological effects of smoking, while the schedule-controlled smoking model should be useful for studying the physiological effects of smoking and for studying the relationship of smoking with various disease entities.

Key words

Cigarette smoking Voluntary smoking Nicotine-free cigarettes Schedule-controlled smoking Rhesus monkeys 

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References

  1. Deneau GA, Inoki R (1967) Nicotine self-administration in monkeys. Ann NY Acad Sci 142:4277–4279Google Scholar
  2. Ferster CB, Skinner BF (1957) Schedules of reinforcement. Appleton-Century-Crofts. New York, p 415Google Scholar
  3. Jarvik ME (1967) Tobacco smoking in monkeys. Ann NY Acad Sci 142:280–294Google Scholar
  4. Jarvik ME (1973) Further observations in nicotine as the reinforcing agent in smoking. In: Dunn WL Jr (ed) Smoking behavior: motives and incentives. Winston, Washington D.C., p 33Google Scholar
  5. Jarvik ME, Gritz ER (1977) Nicotine and tobacco. In: Jarvik ME (ed) Psychopharmacology in the practice of medicine. Appleton-Century-Crofts, New York, p 483Google Scholar
  6. Numata H, Yanagita T (1979) Serum nicotine levels in cigarette-smoking monkeys and human (In Japanese with English abstract). Jap J Clin Pharmacol 10:253–255Google Scholar
  7. Pickens R, Thompson T (1972) Simple schedules of drug self-administration. In: Singh JM, Miller LH, Lals H (eds) Drug addiction: experimental pharmacology, vol 1. Futura New York, p 107Google Scholar
  8. Pickens R, Thompson T, Muchow DC (1973) Cannabis and phencyclidine self-administration by animals. In: Goldberg L, Hoffmeister F (eds) Psychic dependence. Springer, Berlin Heidelberg New York, p 78Google Scholar
  9. Pieper WA, Cole JM (1973) Operant control of smoking in great apes. Behav Res Meth Instru 5:4–6Google Scholar
  10. Robinson GD, Siegel RK, Johnson CA (1974) Evaluation of learned “puffing response” of monkeys with In-113 labeled smoke (abstract). J nucl Med 15:228Google Scholar
  11. Russell MAH (1976) Tobacco smoking and nicotine dependence. In: Gibbins RJ, Israel Y, Kalant H, Popham RE, Schmidt W, Smart RG (eds) Recent advances in alcohol and drug problems, vol 3. John Wiley and Sons, New York, p 1Google Scholar
  12. Siegel RK, Johnson CA, Brewster JM, Jarvik ME (1976) Cocaine self-administration in monkeys by chewing and smoking. Pharmacol Biochem Behav 4:461–467Google Scholar
  13. Yanagita T, Ando K, Oinuma N, Ishida K (1974) Intravenous self-administration of nicotine and an attempt to produce smoking behavior in monkeys. Proceedings of the 36th annual scientific meeting, Committee on Problems of Drug Dependence, National Academy of Sciences, Washington, p 567Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Kiyoshi Ando
    • 1
  • Tomoji Yanagita
    • 1
  1. 1.Department of Psychopharmacology, Preclinical Research LaboratoriesCentral Institute for Experimental AnimalsKawasakiJapan

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