Abstract
The exploratory behavior of pigs was studied in two successive daily 20-mn sessions in a two-compartment box by counting the number of crossings from one compartment to the other and observing the activity patterns. Injection of 1 mg/kg diazepam before the first session increased the number of crossings without affecting the temporal decline of activity within the session; treated pigs did not attempt to escape the experimental situation and tended to be more perseverative in their activity patterns than control pigs. Injected before the second session, diazepam did not modify the exploratory behavior. There was no evidence of a state-dissociation effect in experimental groups for which the treatment condition differed from one session to the other. These results are discussed with respect to current theories about the behavioral effects of benzodiazepines.
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Ahteé, L., Shillito, E.: The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. Brit. J. Pharmacol. 40, 361–371 (1970)
Archer, J.: Tests for emotionality in rats and mice: A review. Anim. Behav. 21, 205–235 (1973)
Beilharz, R. G., Cox, D. F.: Genetic analysis of open-field behavior in swine. J. anim. Sci. 26, 988–990 (1967)
Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970)
Dantzer, R.: Effects of diazepam on behaviour suppressed by extinction in pigs. Pharmacol. Biochem. Behav. (1977, in press)
Dantzer, R., Mormede, P.: Fear-dependent variations in continuous avoidance behavior of pigs. I. Lack of effect of diazepam on performance of discriminative fear conditioning. Psychopharmacology 49, 69–73 (1976)
Dantzer, R., Mormeda, P., Favre, B.: Fear-dependent variations in continuous avoidance behavior of pigs. II. Effects of diazepam on acquisition and performance of Pavlovian fear conditioning and plasma corticosteroid levels. Psychopharmacology 49, 75–78 (1976)
Fraser, D.: The vocalization and other behaviour of growing pigs in an “open-field” test. Appl. anim. Ethol. 1, 3–16 (1974)
Geller, I., Kulak, J. T., Jr., Seifter, J.: The effects of chlordiazepoxide and chlorpromazine on a punishment dicrimination. Psychopharmacologia (Berl.) 3, 374–385 (1962)
Hinde, R. A.: Animal behaviour. A synthesis of ethology and comparative psychology, New York: McGraw Hill 1970
Itoh, H., Takaori, S.: Effects of psychotropic agents on the exploratory behavior of rats in a Y-shaped box. Jap. J. Pharmacol. 18, 344–352 (1968)
Kumar, R.: Extinction of fear II: Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971)
Margules, D. L., Stein, L.: Neuroleptics vs. transquilizers: Evidence from animal behavior studies of mode and site of action. Excerpta Medica Intern. Congr. Ser. 129, 108–120 (1966)
Marriott, A. S., Spencer, P. S. J.: Effects of centrally acting drugs on exploratory behaviour in rats. Brit. J. Pharmacol. 25, 432–511 (1965)
Marriott, A. S., Smith, E. F.: An analysis of drug effects in mice exposed to a simple novel environment. Psychopharmacologia (Berl.) 24, 397–406 (1972)
Meese, G. B., Ewbank, R.: Exploratory behaviour and leadership in the domesticated pig. Anim. Behav. 21, 326–334 (1973)
Overton, D. A.: Experimental methods for the study of state-dependent learning. Fed. Proc. 33, 1800–1813 (1974)
Shillito, E. E.: A method for investigating the effect of drugs on the exploratory behaviour of mice. Brit. J. Pharmacol. 40, 113–123 (1970)
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Dantzer, R. Etude des effets du diazépam sur le comportement explorateur du Porc. Psychopharmacology 51, 317–321 (1977). https://doi.org/10.1007/BF00431643
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DOI: https://doi.org/10.1007/BF00431643