Abstract
Three hamadryas adult baboons (female) received 24 daily injections of Chlorimipramine (1.7 mg/kg). The effects on sleep were nearly identical with the effects observed in man. PGO activity, recorded in the lateral geniculate nucleus, was much disturbed. The total number of PGO fell downward from the first recording. The number of PGO/min during paradoxial sleep was even more decreased. This fact suggests a selective influence of CL I on the mechanisms of PGO activity. Is the particular effect of importance to the treatment of depression symptoms?
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Balzamo, E., Bert, J.: Discordance des effets de la réserpine sur les pointes dites «PGO» chez un primate et chez le chat. Rev. E.E.G. Neurophysiol. 4, 505–506 (1974)
Bert, J., Balzamo, E.: Complexité de l'activité de pointes dites «PGO» chez un primate. Rev. E.E.G. (Paris) 4, 501–504 (1974)
Dunleavy, D. L. P., Brezinova, V., Oswald, I., Maclean, A. W., Tinker, M.: Changes during weeks in effects of tricyclic drugs on the human sleeping brain. Brit. J. Psychiat. 12, 663–672 (1972)
Froment, J. L., Eskazan, E., Jouvet, M.: Effets du LSD et du méthysergide sur les états de sommeil du chat. C.R. Soc. Biol. (Paris), cite in M. Jouvet: The role of monoamines and acetylcholine containing neurons in the regulation of the sleepwaking cycle. Ergebn. Physiol. 64, 166–307 (1972)
Jouvet, M.: Le rêve. Recherche 5, 515–527 (1974)
Morgane, P. J., Stern, W. C.: Chemical anatomy of brain circuits in relation to sleep and wakefulness. Advances in Sleep Research, Vol. 1. New York: Spectrum Publication 1974
Passouant, P., Cadilhac, J., Ribstein, M.: Les privations de sommeil avec mouvements oculaires par les anti-dépresseurs. Rev. neurol. 127, 173–192 (1972)
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Bert, J., Saier, J., Tognetti, P. et al. Effet de la chlorimipramine sur l'activité de pointes «Ponto-Géniculo-Occipitales» (PGO) du babouin Papio hamadryas. Psychopharmacology 51, 301–304 (1977). https://doi.org/10.1007/BF00431640
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DOI: https://doi.org/10.1007/BF00431640