Urological Research

, Volume 22, Issue 1, pp 21–23 | Cite as

Comparison of two routes of photosensitizer administration for photodynamic therapy of bladder cancer

  • R. Bachor
  • R. Hautmann
  • T. Hasan
Original Paper

Abstract

Photodynamic therapy (PDT) consists in administration of a photosensitizer and subsequent irradiation of the tumor with visible light. Routinely the photosensitizer is given intravenously (i.v.). The goal of our study was to examine whether intravesical (i.b.) instillation of the photosensitizer for PDT of bladder cancer might be feasible. Therefore, the uptake of chlor-aluminum-sulfonated phthalocyanine (CASPc) in bladder, bladder tumor, skin, and muscle in a rat bladder cancer model after i.v. injection and i.b instillation was compared. The efficacy of PDT after either method of administration was also evaluated. The CASPc concentration in bladder tumor after i.v. injection was approximately 1.5-fold that after i.b. instillation. The ratio of CASPc concentration between bladder tumor and normal bladder was approximately 2:1 after administration by either route. There was no systemic absorption of CASPc after i.b. instillation; hence no systemic side effects are expected. PDT showed similar effects on bladder tumor after either method of administration, but less side effects on normal bladder wall after i.b instillation. Our results demonstrate that i.b. instillation of CASP for PDT of superficial bladder cancer seems to have advantages over i.v. injection.

Key words

Bladder cancer Photodynamic therapy Intravenous injection Intravesical instillation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D'Hallewin MA, Baert L, Marijnissen JPA, Star WM (1992) Whole bladder wall photodynamic therapy with in situ light dosimetry for carcinoma in situ of the bladder. J Urol 148:1152Google Scholar
  2. 2.
    Dougherty TJ (1987) Photosensitizers: therapy and detection of malignant tumors. Photochem Photobiol 45:879Google Scholar
  3. 3.
    Fingar VH, Schuschke DA, Harty JI, Wieman TJ (1990) A new animal model for the assessment of photodynamic effects on the bladder. Photochem Photobiol 51 S:75Google Scholar
  4. 4.
    Harney JV, Wahl RL, Liebert M, Kuhl DE, Hutchins GD, Wedemeyer G, Grossman HB (1991) Uptake of 2-deoxy, 2-(18F) fluoro-d-glucose in bladder cancer: animal localization and initial patient positron emission tomography. J Urol 145:279Google Scholar
  5. 5.
    Harty JI, Amin M, Wieman TJ, Tseng MT, Ackerman D, Broghamer W (1989) Complications of whole bladder dihematoporphyrin ether photodynamic therapy. J Urol 141:1341Google Scholar
  6. 6.
    Henderson BW, Dougherty TJ (1992) How does photodynamic therapy work? Photochem Photobiol 55:145Google Scholar
  7. 7.
    Ibrahiem EHJ, Nigam VN, Brailovsky CA, Madarnas P, Elhilali M (1983) Orthotopic implantation of primary n-(4-(5-nitro-2-furyl)-2-thiazolyl) formamide-induced bladder cancer in bladder submucosa: an animal model for bladder cancer study. Cancer Res 43:617Google Scholar
  8. 8.
    Jocham D, Baumgartner R, Stepp H, Unsöld E (1990) Clinical experience with the integral, photodynamic therapy of bladder carcinoma. J Photochem Photobiol [B] 6:183Google Scholar
  9. 9.
    Naito K, Hisazumi H, Uchibayashi T, Amano T, Hirata A, Komatsu K, Ishida T, Miyoshi N (1991) Integral laser photodynamic treatment of refractory multifocal bladder tumors. J Urol 146:1541Google Scholar
  10. 10.
    Nseyo UO (1992) Photodynamic therapy. Urol Clin North Am 19:591Google Scholar
  11. 11.
    Pope AJ, Bown SG (1991) The morphological and functional changes in rat bladder following photodynamic therapy with phthalocyanine photosensitization J Urol 145:1064Google Scholar
  12. 12.
    Pope AJ, MacRobert AJ, Phillips D, Bown SG (1991) The detection of phthalocyanine fluorescence in normal rat bladder wall using sensitive digital imaging microscopy. Br J Cancer 64:875Google Scholar
  13. 13.
    Prout GR, Lin CW, Benson R, Nseyo UO, Daly JJ, Griffin PP, Kinsey J, Tian ME, Lao YH, Mian YZ, Chen X, Ren FM, Qiao SJ (1987) Photodynamic therapy with hematoporphyrin derivative in the treatment of superficial transitional cell carcinoma of the bladder. N Engl J Med 317:1251Google Scholar
  14. 14.
    Roberts WG, Smith KM, McCullough JL, Berns MW (1989) Skin photosensitivity and photodestruction of several potential photodynamic sensitizers. Photochem Photobiol 49:431Google Scholar
  15. 15.
    Selman SH, Kreimer-Birnbaum M, Chaudhuri K, Garbo GM, Seaman DA, Keck RW, Ben-Hur E, Rosenthal J (1986) Photodynamic treatment of transplantable bladder tumors in rodents after pretreatment with chloraluminum tetrasulfo-phtalocyanine. J Urol 136:141Google Scholar
  16. 16.
    Spikes JD (1986) Phthalocyanines as photosensitizers in biological systems and for the photodynamic therapy of tumors. Photochem Photobiol 43:691Google Scholar
  17. 17.
    Taari K, Talja M, Riihelä M, Rannikko S, Mokka R (1992) Morphological effects of photodynamic therapy on rabbit bladder using Photofrin II and Photosan intravesically and intravenously. Br J Urol 70:616Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • R. Bachor
    • 1
    • 2
  • R. Hautmann
    • 1
  • T. Hasan
    • 2
  1. 1.Urologische UniversitätsklinikUlmGermany
  2. 2.Wellman Laboratories of PhotomedicineHarvard UniversityBostonUSA

Personalised recommendations