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Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism

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Abstract

RS 86, a specific muscarinic agonist, was evaluated in a blind, placebo-controlled, single-dose trial in 10 psychiatric patients with stable tardive dyskinesia (TD). RS 86, 0.5–4 mg orally, produced no significant effects in TD, although 4 mg caused a minimal aggravation in parkinsonism. Side effects of the highest dose (4 mg) included hypersalivation (eight patients), nausea (6), sweating (3), and vomiting (3). It is concluded that treatmetn with RS 86 and probably other cholinomimetics has no or only limited beneficial effect in TD.

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Authors and Affiliations

  1. Dept. AEH, Sct Hans Hospital, Roskilde, Denmark

    U. Noring, U. Juul Povlsen, D. E. Casey & J. Gerlach

  2. Depts. of Psychiatry and Neurology, VA Medical Center and Oregon Health Sciences University, Portland, Oregon, USA

    D. E. Casey

Authors
  1. U. Noring
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  2. U. Juul Povlsen
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  3. D. E. Casey
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  4. J. Gerlach
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Noring, U., Juul Povlsen, U., Casey, D.E. et al. Effect of a cholinomimetric drug (RS 86) in tardive dyskinesia and drug-related parkinsonism. Psychopharmacology 84, 569–571 (1984). https://doi.org/10.1007/BF00431469

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  • DOI: https://doi.org/10.1007/BF00431469

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