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Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat

Abstract

Chronic oral administration of cannabis extract to rats was examined for its residual effects on shuttle-box avoidance learning. In experiment 1 avoidance learning was assessed in rats that had been tested previosly on other behavioral tests. Chronic treatment (3 months) facilitated the learning of shuttle-box avoidance in cannabis-treated animals relative to vehicle controls. In experiment 2 very similar results were obtained in naive rats. These and other residual effects of chronic cannabis treatment are similar to the effects of hippocampal lesions.

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References

  1. Blanchard RJ, Fial RA (1968) Effects of limbic lesions on passive avoidance and reactivity to shock. J Comp Physiol Psychol 66:606–612

    Google Scholar 

  2. Clark CVW, Isaacson RL (1965) Effect of bilateral hippocampal ablation on DRL performance. J Comp Physiol Psychol 59:137–140

    Google Scholar 

  3. Fehr K, Kalant H, LeBlanc AE (1976) Residual learning deficit after heavy exposure to cannabis or alcohol in rats. Science 193:1249–1251

    Google Scholar 

  4. Isaacson RL, Douglas RJ, Moore RY (1961) The effect of radical hippocampal ablation on acquisition of avoidance response. J Comp Physiol Psychol 54:625–628

    Google Scholar 

  5. Johnson CT, Olton DS, Gage FH, Jenko PG (1977) Hippocampal connections and the integration of behavior. J Comp Physiol Psychol 91:508–522

    Google Scholar 

  6. Kapp BS, Gallagher M, Holmquist BK, Theall CL (1978) Retrograde amnesia and hippocampal stimulation: Dependence upon the nature of associations formed during conditioning. Behav Neural Biol 24:1–23

    Google Scholar 

  7. Kimble DP (1975) Choice behavior in rats with hippocampal lesions. In: Isaacson RL, Pribram KH (eds) The hippocampus, vol 2. Plenum, New York, pp 309–326

    Google Scholar 

  8. Kimble DP (1978) Effects of combined entorhinal cortex-hippocampal lesions on locomotor behavior, spontaneous alternation and spatial maze learning in the rat. Physiol Behav 21:177–187

    Google Scholar 

  9. Klausner HA, Dingell JV (1971) The metabolism and excretion of Δ 9-tetrahydrocannabinol in the rat. Life Sci 10:49–59

    Google Scholar 

  10. Myhrer T (1975) Locomotor avoidance and maze behavior in rats with selective disruption of hippocampal output. J Comp Physiol Psychol 89:759–777

    Google Scholar 

  11. Olton DS, Isaacson RL (1968) Hippocampal lesions and active avoidance. Physiol Behav 3:719–724

    Google Scholar 

  12. Olton DS, Walker JA, Gage FH (1978) Hippocampal connections and spatial discrimination. Brain Res 139:295–308

    Google Scholar 

  13. Radouco-Thomas S, Magnan F, Grove RN, Singh P, Garcin F, Radouco-Thomas C (1976) Effect of chronic administration of Δ 1-tetrahydrocannabinol on learning and memory in developing mice. In: Braude MC, Szara S (eds) Pharmacology of marihuana, vol 2. Raven, New York, pp 487–498

    Google Scholar 

  14. Rickert EJ, Bennet TL, Anderson GJ, Corbett J, Smith L (1973) Differential performance of hippocampally ablated rats on non-discriminated and discriminated DRL schedules. Behav Biol 8:597–609

    Google Scholar 

  15. Rosenkrantz H (1983) Cannabis, marihuana, and cannabinoid toxicological manifestations in man and animals. In: Fehr KO, Kalant H (eds) Proceedings of an ARF/WHO scientific meeting on adverse and behavioral consequences of cannabis use, Toronto, Canada, 1981. Addiction Research Foundation, Toronto, pp 91–175

    Google Scholar 

  16. Stiglick A, Kalant H (1982a) Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats. Psychopharmacology 77:117–123

    Google Scholar 

  17. Stiglick A, Kalant H (1982b) Residual effects of prolonged cannabis administration on exploration and DRL performance in rats. Psychopharmacology 77:124–128

    Google Scholar 

  18. Winer BJ (1971) Statistical principles in experimental design. McGraw Hill, New York

    Google Scholar 

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Correspondence to Harold Kalant.

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Stiglick, A., Llewellyn, M.E. & Kalant, H. Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat. Psychopharmacology 84, 476–479 (1984). https://doi.org/10.1007/BF00431452

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Key words

  • Chronic cannabis
  • Shuttle-box avoidance