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Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat

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Chronic oral administration of cannabis extract to rats was examined for its residual effects on shuttle-box avoidance learning. In experiment 1 avoidance learning was assessed in rats that had been tested previosly on other behavioral tests. Chronic treatment (3 months) facilitated the learning of shuttle-box avoidance in cannabis-treated animals relative to vehicle controls. In experiment 2 very similar results were obtained in naive rats. These and other residual effects of chronic cannabis treatment are similar to the effects of hippocampal lesions.

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Stiglick, A., Llewellyn, M.E. & Kalant, H. Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat. Psychopharmacology 84, 476–479 (1984).

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