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The role of conditional drug responses in tolerance to the hypothermic effects of ethanol

Abstract

The role of predrug cues in tolerance to ethanol-induced hypothermia was investigated in two experiments. The results of Experiment 1 demonstrated that tolerance was displayed only when the drug was administered in conjunction with environmental stimuli that had, in the past, accompanied ethanol administration. A conditional hyperthermic response was elicited when a placebo, instead of ethanol, was administered in conjunction with the usual ethanol cues. Results of Experiment 2 suggested that tolerance to ethanol-induced hypothermia can be extinguished by repeated placebo injections. These results indicate that associative processes, previously demonstrated to modulate opiate tolerance, also modulate ethanol tolerance.

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Correspondence to Shepard Siegel.

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Crowell, C.R., Hinson, R.E. & Siegel, S. The role of conditional drug responses in tolerance to the hypothermic effects of ethanol. Psychopharmacology 73, 51–54 (1981). https://doi.org/10.1007/BF00431101

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Key words

  • Tolerance
  • Pavlovian conditioning
  • Ethanol hypothermia
  • Drug-compensatory responses
  • With-drawal symptoms