Virchows Archiv A

, Volume 393, Issue 2, pp 205–214 | Cite as

Cell kinetic and cytological grading of prostatic carcinoma

  • Burkhard Helpap
Original Articles

Summary

In 69 cases of prostatic carcinomas the 3H-thymidine labelling index was studied, and a cytological analysis was performed in addition to the histological classification. The following cytological variables were measured: nuclear size and shape, nuclear-cytoplasmic-ratio, nuclear chromasia, size and form of nucleoli.

Only prostatic carcinomas with a labeling index of less than 0.4% showed mild nuclear anaplasia. These carcinomas were histologically classified as well differentiated adenocarcinomas. Prostatic carcinomas with a labelling index from 0.4% to 1.0% showed moderate nuclear anaplasia. These carcinomas were poorly differentiated adenocarcinomas. Carcinomas with labeling indices between 1.4 and 2.3% had moderate — marked nuclear anaplasia and exhibited a transition to undifferentiated carcinomas. Carcinomas with a labelling index higher than 2.3% were cribriform and undifferentiated carcinomas with marked nuclear anaplasia.

The present studies have shown a correlation between both histological classification and cytological appearances with indicators of cell kinetics.

Key words

Prostatic carcinoma Histology Cytology Autoradiography Grading 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Burkhard Helpap
    • 1
  1. 1.Pathologisches Institut der Universität BonnBonn 1Federal Republic of Germany

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