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The effect of changes in cardiac frequency on left and right ventricular dP/dt max at different contractile states of the myocardium

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Summary

In 17 canine heart-lung preparations the dependence of frequency potentiation of the right and left ventricular myocardium on the basic inotropic state of the heart was investigated. The effect of unipolar stimulation of the right atrium on dP/dt max in both ventricles was measured. The aortic pressure was maintained constant.

Shortly after isolation of the heart, a stepwise increase of rate from 140 to 200 beats/min only had a very weak influence on left ventricular dP/dt max. With deterioration of the myocardium the frequency potentiation of dP/dt max increased considerably. End-diastolic pressure regularly decreased with rising cardiac frequency. Since the real positive inotropic effect is masked by the concomitant fall in diastolic loading, the end-diastolic pressure was maintained constant in a second group of 8 hearts during rate variation. The most pronounced inotropic effect was now found shortly after isolation of the heart. A rate increase of 30 beats/min resulted in a 20% rise of dP/dt max. The frequency potentiation decreased with deterioration of the heart resulting in a 12% dP/dt max increase at an estimated inotropic state of 50% of control. When the contractile state of the heart was improved above the control state by calcium application the frequency potentiation of the myocardium decreased.

In the right ventricle similar results were obtained except for the fact that no significant correlation between the steepness of the frequency characteristics and the contractile state of the heart could be found when the end-diastolic pressure was kept constant.

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References

  • Baumann, K., Reichel, H.: Time dependence of frequency potentiation in the isolated guinea pig atrium. Pflügers Arch. 350, 69–80 (1974)

    Google Scholar 

  • Benchimol, A., Liggett, M. S.: Cardiac hemodynamics during stimulation of the right atrium, right ventricle and left ventricle in normal and abnormal hearts. Circulation 37, 933–944 (1966)

    Google Scholar 

  • Berglund, E., Borst, H. G., Duff, F., Schreiner, G. L.: Effect of heart rate on cardiac work, myocardial oxygen consumption and coronary blood flow in the dog. Acta Physiol. Scand. 42, 185–198 (1958)

    Google Scholar 

  • Bishop, S. V., Horwitz, L. D.: Influence of the cardiac sympathetics of left ventricular dynamics during tachycardia. Cardiology 58, 326–334 (1973)

    Google Scholar 

  • Boerth, R. C., Covell, J. W., Pool. P. E., Ross, J., Jr.: Increased myocardial oxygen consumption and contractile state associated with increased heart rate in dogs. Circ. Res. 24, 725–734 (1969)

    Google Scholar 

  • Cotton, M.: Circulatory changes affecting measurements of heart force in situ with strain gauge arches. Am. J. Physiol. 174, 365–370 (1953)

    Google Scholar 

  • Covell, J. W., Ross, J., Taylor, R., Sonnenblick, E. H., Braunwald, E.: Effects of increasing frequency of contraction on the force velocity relation of left ventricle. Cardiovasc. Res. 1, 2–8 (1967)

    Google Scholar 

  • Furnival, C. M., Linden, R. J., Snow, H. M.: Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure, and end-diastolic pressure. J. Physiol. (Lond.) 211, 359–387 (1970)

    Google Scholar 

  • Gilmore, J. P., Cingolani, H. E., Taylor, R. R., Powell, W. J.: Influence of ventricular activation on ventricular compliance. Am. J. Physiol. 211, 1127–1231 (1966)

    Google Scholar 

  • Gobel, F. L., Medina, J. R., Guenther, C. A., Wang, Y.: Immediate hemodynamic response of patients with atrioventricular block and cardiac failure to transvenous pacing. Circulation 39, 64–71 (1969)

    Google Scholar 

  • Gobel, F. L., Jorgensen, C. R., Kitamuta, K., Wang, Y.: Acute changes in left ventricular volume and contractility during ventricular pacing in patients with complete heart block. Circulation 44, 771–781 (1971)

    Google Scholar 

  • Higgins, C. F., Vatner, S. D., Franklin, D., Braunwald, E.: Extent of regulation of the heart's contractile state in the conscious dog by alteration in the frequency of contraction. J. Clin. Invest. 52, 1187–1194 (1973)

    Google Scholar 

  • Hoppe, H., Schmidt, H. D., Seitz, E.: The maximal rate of pressure rise in the right ventricle of isolated canine hearts in isovolumic and auxotonic systole under various hemodynamic and inotropic conditions. Bas. Res. Cardiol. 71, 530–541 (1976)

    Google Scholar 

  • Jakob, R., Kissling, G., Segarra-Domenech, J.: SteigerungsfÄhigkeit von Kontraktionsgeschwindigkeit und Schlagvolumen durch inotrope Mechanismen beim intakten Herzen in situ. Arch. Kreislaufforsch. 57, 291–323 (1968)

    Google Scholar 

  • Kahn, M. C., Kavaler, F., Fisher, V. J.: Frequency-force relationships of mammalian ventricular muscle in vivo and in vitro. Am. J. Physiol. 230, 631–636 (1976)

    Google Scholar 

  • Kavaler, F., Harris, R. S., Lee, R. J., Fisher, V. J.: Frequency-force behaviour of in situ ventricular myocardium in the dog. Circ. Res. 28, 533–544 (1971)

    Google Scholar 

  • Knowlton, F. P., Starling, E. H.: The influence of variations in temperature and blood pressure on the performance of the isolated mammalian heart. J. Physiol. (Lond.) 44, 206–219 (1912)

    Google Scholar 

  • Koch-Weser, J., Blinks, J. R.: The influence of the interval between beats on myocardial contractility. Pharmacol. Rev. 15, 601–652 (1963)

    Google Scholar 

  • Koch-Weser, J.: Role of norepinephrine release in the interval-strength relationship of heart muscle. J. Pharmacol. Exp. Ther. 150, 184–189 (1965)

    Google Scholar 

  • Krayer, O., Schütz, E.: Mechanische Leistung und einphasisches Elektrogramm am Herz-Lungen-PrÄparat des Hundes. Z. Biol. 92, 453–461 (1932)

    Google Scholar 

  • Leighton, F. R., Zavon, S. J., Robinson, J. L., Weissler, A. M.: Effects of atrial pacing on left ventricular performance in patients with heart disease. Circulation 40, 615–622 (1969)

    Google Scholar 

  • Limbourg, P., Wende, W., Heinrich, M., Peiper, U.: Frequenzinotropie und Frank-Starling-Mechanismus am Hundeherzen in situ unter natürlichem und künstlichem Herzantrieb. Pflügers Arch. 322, 250–263 (1971)

    Google Scholar 

  • McLaurin, L. P., Rolett, E. L., Grossman, W.: Impaired left ventricular relaxation during pacing-induced ischemia. Am. J. Cardiol. 32, 751–757 (1973)

    Google Scholar 

  • Mitchell, J. H., Wallace, A. G., Skinner, N. S.: Intrinsic effects of heart rate on left ventricular performance. Am. J. Physiol. 205, 41–48 (1963)

    Google Scholar 

  • Monroe, R. G., French, G. N.: Left ventricular pressure-volume relationships and myocardial oxygen consumption in the isolated heart. Circ. Res. 9, 362–374 (1961)

    Google Scholar 

  • Monroe, R. G., La Farge, C. G., Gamble, W. J., Hammond, R. P., Gamboa, R.: Left ventricular performance and blood catecholamine levels in the isolated heart. Am. J. Physiol. 211, 1248–1254 (1966)

    Google Scholar 

  • Niedergerke, R.: The “staircase” phenomen and the action of calcium on the heart. J. Physiol. 134, 569–583 (1956)

    Google Scholar 

  • Noble, M. I. M., Wyler, J., Milne, E. N. C., Tranchard, S., Guz, A.: Effect of changes in heart rate on left ventricular performance in conscious dogs. Circ. Res. 24, 285–295 (1969)

    Google Scholar 

  • Patterson, S. W., Piper, H., Starling, E. H.: The regulation of the heart beat. J. Physiol. 48, 465–513 (1914)

    Google Scholar 

  • Pitt, B., Gregg, D. E.: Coronary hemodynamic effects of increasing ventricular rate in the unanaesthetized dog. Circ. Res. 22, 753–761 (1968)

    Google Scholar 

  • Reeck, S., Hoppe, H., Schmidt, H. D.: Performance of the heart-lung preparation of puppies. Pflügers Arch. [Suppl.] 355, R 13 (1975)

    Google Scholar 

  • Reichel, H., Rumberger, E., SchÄfer, J., Schwarzkopf, H. J., Baumann, K.: Frequency-potentiation in the human myocardium. Bas. Res. Cardiol. 69, 11–20 (1974)

    Google Scholar 

  • Reichel, H.: The effect of isolation on myocardial properties. Bas. Res. Cardiol. 71, 1–16 (1976)

    Google Scholar 

  • Sarnoff, S. J., Mitchell, J. H., Gilmore, J. P., Remensnyder, J. P.: Homeometric autoregulation in the heart. Circ. Res. 8, 374–383 (1959)

    Google Scholar 

  • Schmidt, H. D., Hoppe, H., Schneider, W.: Usefulness of some pressure velocity parameters for evaluation of left ventricular contractility. Verh. Dtsch. Ges. Kreisl.-Forsch. 39, 151–156 (1973)

    Google Scholar 

  • Schmidt, H. D., Hoppe, H., Jotzo, R.: The inotropic sensitivity of dP/dt max and ventricular function curves. A comparison study on isolated canine hearts. Pflügers Arch. [Suppl.] 355, R 15 (1975)

    Google Scholar 

  • Schmidt, H. D., Hoppe, H.: Maximal rate of pressure rise and time parameters in the right ventricle under isovolumic conditions. Investigations in the canine heart-lung preparation. Bas. Res. Cardiol. 71, 521–529 (1976)

    Google Scholar 

  • Schmidt, H. D., Hoppe, H.: Preload dependence of dP/dt max, VCE max, and calculated V max compared to the inotropic sensitivity of these indices of cardiac contractility. Bas. Res. Cardiol. 73, 380–393 (1978a)

    Google Scholar 

  • Schmidt, H. D., Hoppe, H.: Influence of the contractile state of the heart on the preload dependence of the maximal rate of intraventricular pressure rise dP/dt max. Cardiology 63, 112–125 (1978b)

    Google Scholar 

  • Sonnenblick, E. H.: Force-velocity relations in mammalian heart muscle. Am. J. Physiol. 202, 931–939 (1962)

    Google Scholar 

  • Sonnenblick, E. H., Morrow, A. G., Williams, J. F.: Effects of heart rate on the dynamics of force development in the intact human ventricle. Circulation 33, 945–951 (1966)

    Google Scholar 

  • Tuttle, R. S., Farah, A.: The effect of onabain on the frequency-force relation and on post-stimulation potentiation in isolated atrial and ventricle muscle. J. Pharmacol. Exp. Ther. 135, 142–150 (1962)

    Google Scholar 

  • Wende, W., Henrich, H., Limbourg, P., Peiper, U., Bauereisen, E.: Vergleichende Untersuchung über die Wirkung adrenerger cholinerger und durch künstlichen Antrieb verursachter FrequenzÄnderungen auf die Dynamik des Herzens in situ. Arch. Kreislauf-Forsch. 64, 82–97 (1971)

    Google Scholar 

  • Whalen, W. J., Fishman, N., Erickson, R.: Nature of the potentiating substance in carciac muscle. Am.: J. Physiol. 194, 573–580 (1958)

    Google Scholar 

  • Winegard, S.: The possible role of calcium in excitation-contraction coupling of heart muscle. Circulation 24, 523–529 (1961)

    Google Scholar 

  • Wood, E. H., Heppner, R. L., Weidmann, S.: I. Positive and negative effects of constant electric currents or current pulses applied during cardiac action potentials. II. Hypotheses: Calcium movements, excitation-contraction coupling and inotropic effects. Circ. Res. 24, 409–445 (1969)

    Google Scholar 

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Authors and Affiliations

  1. Institut für Physiologie der Freien UniversitÄt Berlin, Arnimallee 22, D-1000, Berlin

    Hanno Dieter Schmidt, Hans Hoppe & Klaus Dieter Müller

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  1. Hanno Dieter Schmidt
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  2. Hans Hoppe
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  3. Klaus Dieter Müller
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Schmidt, H.D., Hoppe, H. & Müller, K.D. The effect of changes in cardiac frequency on left and right ventricular dP/dt max at different contractile states of the myocardium. Europ. J. Appl. Physiol. 42, 183–198 (1979). https://doi.org/10.1007/BF00431025

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