Virchows Archiv A

, Volume 397, Issue 1, pp 109–119 | Cite as

Epithelioid sarcoma

Enzyme histochemical and ultrastructural study
  • R. Machinami
  • F. Kikuchi
  • H. Matsushita
Case Report


A case of epithelioid sarcoma was studied by electron microscopy and by light and electron microscopic enzyme histochemistry comparing with several control soft tissues. In addition to previously reported ultrastructural features, such as abundant 10 nm cytoplasmic filaments, desmosome-like cell junctions and small cystic spaces surrounded by filopodia or microvilli of the tumor cells, we encountered 10 nm cytoplasmic filaments showing electron dense condensation with a concentrically oriented or whorled pattern and a finger-print-like arrangement and 5′-nucleotidase activity of tumor cell membrane. Among the control soft tissues, 5′-nucleotidase activity was found only in synovial and endothelial cells. Both tumor and synovial cells showed no activity of adenosine triphosphatase, while marked activity of the enzyme was found in endothelial cells. These results support the concept that epithelioid sarcoma is derived from mesenchymal cells undergoing differentiation toward synovial cells during neoplastic transformation.

Key words

Epithelioid sarcoma Ultrastructure 5′-nucleotidase 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • R. Machinami
    • 1
  • F. Kikuchi
    • 2
  • H. Matsushita
    • 3
  1. 1.Department of Pathology, Faculty of MedicineGunma UniversityMaebashi, Gunma 371
  2. 2.Department of Pathology, Faculty of MedicineTokyo UniversityTokyo 113
  3. 3.Department of PathologyToranomon HospitalTokyo 107Japan

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