Virchows Archiv A

, Volume 397, Issue 1, pp 103–108 | Cite as

Oestrogen receptors in human breast cancer

Problems of correlation with histopathological features
  • Hans Skovgaard Poulsen
  • Luciano Ozzello
  • Johan Andersen


Histopathological factors which might explain inconsistency in published data attempting to correlate oestrogen receptor content (ER) and pathological features in primary breast tumours have been investigated in 194 cases. It was found, that unequal assessment of tumour type and of histological grading between observers is one important factor. In terms of grading, however, heterogeneity of growth pattern within the same tumour seems to be of greater significance. No significant correlation was found between histological type of tumour and ER content. However, a trend towards a correlation between the extent of tubule formation (as an indication of differentiation) and ER content was observed.

Key words

Oestrogen receptors Human breast cancer Histopathology 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Hans Skovgaard Poulsen
    • 1
    • 2
  • Luciano Ozzello
    • 2
  • Johan Andersen
    • 3
  1. 1.Department of Surgery IThe Institute of Cancer Research, Aarhus Kommune Hospital RadiumstationenAarhusDenmark
  2. 2.Presbyterian Medical Center, Department of Surgical PathologyCollege of Physicians & Surgeons of Columbia UniversityNew YorkUSA
  3. 3.The Institute of PathologyEsbjergDenmark

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